Mechanisms of Alcohol Extract of Thladiantha dubia Fruits on Secondary Dysmenorrhea-Induced Endometritis

LI Ya-zhou; GAO Chong; HU Xiao-cheng; TONG Ji-ming

doi:10.13422/j.cnki.syfjx.2011.23.064

您当前的位置：

首页 >

文章列表页 >

Mechanisms of Alcohol Extract of Thladiantha dubia Fruits on Secondary Dysmenorrhea-Induced Endometritis

更新时间：2024-09-23

- Mechanisms of Alcohol Extract of Thladiantha dubia Fruits on Secondary Dysmenorrhea-Induced Endometritis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 148-150(2011)
- 作者机构：
  
  承德医学院中药研究所河北省中药研究与开发重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.064
  CLC： R285.5
- Published：2011
- 稿件说明：
移动端阅览
[1]李亚洲,高冲,胡晓丞,佟继铭.赤雹果乙醇提取物治疗子宫内膜炎继发痛经作用机制研究[J].中国实验方剂学杂志,2011,17(23):148-150.

LI Ya-zhou, GAO Chong, HU Xiao-cheng, et al. Mechanisms of Alcohol Extract of Thladiantha dubia Fruits on Secondary Dysmenorrhea-Induced Endometritis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 148-150.
[1]李亚洲,高冲,胡晓丞,佟继铭.赤雹果乙醇提取物治疗子宫内膜炎继发痛经作用机制研究[J].中国实验方剂学杂志,2011,17(23):148-150. DOI： 10.13422/j.cnki.syfjx.2011.23.064.

LI Ya-zhou, GAO Chong, HU Xiao-cheng, et al. Mechanisms of Alcohol Extract of Thladiantha dubia Fruits on Secondary Dysmenorrhea-Induced Endometritis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 148-150. DOI： 10.13422/j.cnki.syfjx.2011.23.064.

摘要

目的:探讨赤雹果乙醇提取物（AETF）治疗继发性痛经的机制。方法:采用植入塑料管法

制备大鼠子宫内膜炎继发性痛经模型。观察AETF对模型大鼠子宫组织匀浆中一氧化氮（NO）、丙二醛（MDA）含量及超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）活性的影响。结果:AETF 0.3

0.6

1.2 g.kg-1剂量组子宫组织匀浆中NO的含量明显低于模型组（P<0.01）

SOD的活性明显高于模型组（P<0.05）;0.6

1.2 g.kg-1剂量组子宫匀浆中MDA的含量明显低于模型组（P<0.01）

GSH-Px的活性显著高于模型组（P<0.05）。结论:AETF治疗继发性痛经作用机制与抑制致炎致痛介质的产生和促进过氧化物的清除有关。

Abstract

Objective:To investigate the mechanisms of the alcohol extract of Thladiantha dubia fruits（AETF） on secondary dysmenorrhea-induced endometritis.Method:The secondary dysmenorrhea model of endometritis was established by implanting the plastic tube into uterus.The effect of AETF on concentration of nitric oxide（NO） and malondialdehyde（MDA）

and the activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px） in homogenate of uterus was observed by adopting the rats model.Result:AETF groups（0.3

0.6

1.2 g·kg-1） clearly decreased concentration of NO and increased activities of SOD

compared with model group（P<0.01 and P<0.05）;AETF groups（0.6

1.2 g·kg-1） clearly decreased concentration of MDA and increased activities of GSH-Px

compared with model group（P<0.01 and P<0.05）.Conclusion: The mechanisms of AETF on secondary dysmenorrhea may be related to the inhibition of inflammatory mediators and pianful mediators

the clearance of peroxides.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Anti-hyperglycemic Effect of Roots Decoction

Protective Effects and Mechanism of Bushen Houxue Fang on Parkinson's Disease Rat Dopaminergic Neurons

Role of Oxidative Stress in Ulcerative Colitis and Traditional Chinese Medicine Prevention and Treatment： A Review

Effect of Nitrogen Application on Antioxidant Enzyme System of Acanthopanax senticosus

Related Author

LI Ya-zhou

GAO Chong

HU Xiao-cheng

TONG Ji-ming

LEI Jun-tao

MO Shao-ling

CHEN Shuang

WANG Jie

Related Institution

Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Shandong University of Traditional Chinese Medicine

School of Forestry, Northeast Forestry University

The First Affiliate Hospital of Clinical Medicine of Guangdong Pharmaceutical University

School of Pharmacy, Heilongjiang University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰