Antidepressant Effects of the Total Flavonoids of Scutellaria baicalensis in Mice

LI Yu-cheng; LI Han-bing; ZHANG Bin

doi:10.13422/j.cnki.syfjx.2011.23.070

您当前的位置：

首页 >

文章列表页 >

Antidepressant Effects of the Total Flavonoids of Scutellaria baicalensis in Mice

更新时间：2024-09-23

- Antidepressant Effects of the Total Flavonoids of Scutellaria baicalensis in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 168-170(2011)
- 作者机构：
  
  河南中医学院药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.070
  CLC： R285.5
- Published：2011
- 稿件说明：
移动端阅览
[1]栗俞程,李寒冰,张宾.黄芩总黄酮对小鼠的抗抑郁作用[J].中国实验方剂学杂志,2011,17(23):168-170.

LI Yu-cheng, LI Han-bing, ZHANG Bin. Antidepressant Effects of the Total Flavonoids of Scutellaria baicalensis in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 168-170.
[1]栗俞程,李寒冰,张宾.黄芩总黄酮对小鼠的抗抑郁作用[J].中国实验方剂学杂志,2011,17(23):168-170. DOI： 10.13422/j.cnki.syfjx.2011.23.070.

LI Yu-cheng, LI Han-bing, ZHANG Bin. Antidepressant Effects of the Total Flavonoids of Scutellaria baicalensis in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 168-170. DOI： 10.13422/j.cnki.syfjx.2011.23.070.

摘要

目的:观察黄芩总黄酮的抗抑郁作用。方法:雄性ICR小鼠分为空白对照组和4个治疗组

其中治疗组连续7 dig给予黄芩总黄酮（25

100 mg.kg-1）和阳性对照药盐酸氟西汀（20 mg.kg-1）。末次给药1 h后

采用强迫游泳、悬尾以及利血平拮抗实验对小鼠进行行为学观察。结果:黄芩总黄酮（50

100 mg.kg-1）和盐酸氟西汀（20 mg.kg-1）均显著缩短小鼠强迫游泳和悬尾不动时间

并显著拮抗利血平所致的小鼠体温下降、运动不能以及眼睑下垂。结论:黄芩总黄酮具有抗抑郁作用

其机制可能涉及单胺能神经系统。

Abstract

Objective:To study the antidepressant effects of the total flavonoids of Scutellaria baicalensis（TFSB） in mice.Method: Male ICR mice were divided into control and four treatment groups.The treatment groups were received TFSB at dose of 25

100 mg·kg-1 and fluoxetine at 20 mg·kg-1 administration for 7 days respectively.Forced swimming test（FST）

tail suspension test（TST） and reserpine reversal test were conducted for behavior evaluation at 1 h after the last administration.Result: 50

100 mg·kg-1 of TFSB and 20 mg·kg-1 of fluoxetine significantly decreased immobility time of mice in both FST and TST.Moreover

100 mg·kg-1 of TFSB significantly antagonize the decrease in body temperature

akinesia and eyelid ptosis induced by reserpine in mice.Conclusion: These results suggested that TFSB possessed potent antidepressant-like properties

and the mechanism may involved in monoaminergic nervous systems.

关键词

Keywords

references

Views

424

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Study on the Antidepressant Effect of Jiaotai Pill with Different Proportions

Screening of Antidepressant Effects of Four Main Flavonoids Compounds from

Antidepressant-like Effect of Banxia Xiexin Tang

Experiment Study on Anti-depressant Effects of Pueraria Isoflavone

Related Author

LI Yu-cheng

LI Han-bing

ZHANG Bin

YU Chun-quan

WANG Yi

GAO Shan

LI Ran

ZHANG Min

Related Institution

Changchun University of Chinese Medicine

Affiliated Hospital of Changchun University of Chinese Medicine

Guangdong College of Pharmacy

Key Laboratory of Chemistry and Engineering of Forest Products， National Ethnic Affairs Commission， Guangxi Key Laboratory of Chemistry and Engineering of Forest Products/Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products， School of Chemistry and Chemical Engineering， Guangxi Minzu University

Guangxi Key Laboratory of Chinese Medicine Quality Standard， Guangxi Institute of Chinese Medicine and Pharmaceutical Science

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰