Effect of Qingchang Granule in Experimental Functional Constipation

SHI Yue-qiang; LIANG Mao-xing; ZHANG Hong

doi:10.13422/j.cnki.syfjx.2011.23.074

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Effect of Qingchang Granule in Experimental Functional Constipation

更新时间：2024-09-23

- Effect of Qingchang Granule in Experimental Functional Constipation
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 184-187(2011)
- 作者机构：
  
  辽宁中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.074
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]石月强,梁茂新,张宏.清肠颗粒对实验性功能性便秘的影响[J].中国实验方剂学杂志,2011,17(23):184-187.

SHI Yue-qiang, LIANG Mao-xing, ZHANG Hong. Effect of Qingchang Granule in Experimental Functional Constipation[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 184-187.
[1]石月强,梁茂新,张宏.清肠颗粒对实验性功能性便秘的影响[J].中国实验方剂学杂志,2011,17(23):184-187. DOI： 10.13422/j.cnki.syfjx.2011.23.074.

SHI Yue-qiang, LIANG Mao-xing, ZHANG Hong. Effect of Qingchang Granule in Experimental Functional Constipation[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 184-187. DOI： 10.13422/j.cnki.syfjx.2011.23.074.

摘要

目的:观察清肠颗粒对实验性功能性便秘的影响。方法:清肠颗粒低、中、高（按生药量计6.5

26 g.kg-1.d-1）剂量组

大黄通便颗粒（3.12 g.kg-1.d-1）组

聚乙二醇4000散剂（5.2 g.kg-1.d-1）组。每天ig给药1次

连续5 d。通过清肠颗粒对小鼠排便时间和数量、肠容积、小肠推进运动等（排便实验、肠容积实验、炭末推进实验）的作用与影响

考察清肠颗粒对实验性功能性便秘的效应。结果:与燥结失水模型组比较

清肠颗粒中、高剂量组小鼠首次排便时间缩短

4 h内排黑便点数增多（P<0.01）;与肠道动力障碍模型组比较

清肠颗粒低、中、高剂量组缩短小鼠首次排黑便时间并增加4 h内排黑便点数（P<0.01

P<0.05）;与空白对照组比较

清肠颗粒随剂量增加小鼠排便时间缩短

排便数增多（P<0.01）;与空白对照组比较清肠颗粒低、中、高剂量组肠管质量明显增加（P<0.05

P<0.01）;碳墨推进距离与空白对照组比较明显增长（分别P<0.05

P<0.01）。结论:清肠颗粒能够明显促进小鼠排便

显著减少肠道对水分的吸收

具有增加肠管容积、增强正常小鼠肠蠕动和促进小肠推进运动的作用。

Abstract

Objective:To observe the effect of Qingchang granule in experimental functional constipation.Method: Qingchang granule low

medium and high（6.5

26 g·kg-1·d-1）dose group

Dahuang Tongbian Keli（3.12 g·kg-1·d-1）group

polyethylene glycol PEG 4 000 powder（5.2 g·kg-1·d-1） group.ig every day to medicine

the continuous 5 d.To investigate the role of Qingchang granule in the time and number of defaecation

volume of intestine

propulsive movement of small intestine of the experimental mouse（defaecation experiment

volume of intestine experiment

charcoal powder propulsion experiment）

explore the biological effect of the Qingchang granule in experimental functional Constipation.Result: Dry and water loss model group comparison

Qingchang granule

high dose group of mice

shorten the time required for the first time defecate in row 4 h and black points increased（P<0.01）.And intestinal power obstacles model

Qingchang granule group compared low

medium and high dose group first row black mice and shorten the time and increase in row 4 h black then points（P<0.01

P<0.05）.And blank compared to the Qingchang granule with mice increased defecate time reduced doses

defecate number increased（P<0.01）.And blank compared Qingchang granule low

medium and high quality throughout the obvious increase of the dose group（P<0.05

P<0.01）.Carbon ink distance and promote blank compared increases obviously（P<0.05

P<0.01）.Conclusion:The results indicate that Qingchang granule could promote defecation

decrease the intestine absorbed the moisture

increased volume of intestine

enhanced the enterocinesia and propulsive movement of intestine.

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Related Institution

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