Rat Models of Type 2 Diabetic Retinopathy and the Intervention of Calcium Dobesilate on the Model

SHI Jing-li1; KAN Hong-wei2; WANG Hai-qing2; LIANG Yan2; JIN Kang2; YANG Shi-you4

doi:10.13422/j.cnki.syfjx.2011.23.076

您当前的位置：

首页 >

文章列表页 >

Rat Models of Type 2 Diabetic Retinopathy and the Intervention of Calcium Dobesilate on the Model

更新时间：2024-09-23

- Rat Models of Type 2 Diabetic Retinopathy and the Intervention of Calcium Dobesilate on the Model
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 180-183(2011)
- 作者机构：
  
  1. 安徽中医学院药学院
  2. 安徽省药物研究所
  3. 3. 安徽省药物临床前安全评价中心
  4. 安徽大学生命科学院
  5. 安徽省药品审评认证中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.076
  CLC： R-332;R965
- Published：2011
- 稿件说明：
移动端阅览
[1]石静丽,阚红卫,王海青,梁燕,靳康,杨士友.2型糖尿病大鼠视网膜病变模型的建立及羟苯磺酸钙的干预作用[J].中国实验方剂学杂志,2011,17(23):180-183.

SHI Jing-li1, KAN Hong-wei2, WANG Hai-qing2, et al. Rat Models of Type 2 Diabetic Retinopathy and the Intervention of Calcium Dobesilate on the Model[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 180-183.
[1]石静丽,阚红卫,王海青,梁燕,靳康,杨士友.2型糖尿病大鼠视网膜病变模型的建立及羟苯磺酸钙的干预作用[J].中国实验方剂学杂志,2011,17(23):180-183. DOI： 10.13422/j.cnki.syfjx.2011.23.076.

SHI Jing-li1, KAN Hong-wei2, WANG Hai-qing2, et al. Rat Models of Type 2 Diabetic Retinopathy and the Intervention of Calcium Dobesilate on the Model[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 180-183. DOI： 10.13422/j.cnki.syfjx.2011.23.076.

摘要

目的:建立及评价2型糖尿病大鼠视网膜病变（DR）模型

观察羟苯磺酸钙对DR的干预作用。方法:72只SD大鼠随机分成正常组和造模组。造模组大鼠以高脂饲料喂养3个月后ip STZ（45 mg.kg-1）1次。12周后造模大鼠再随机分为模型组和药物组。药物组每日ig羟苯磺酸钙1次（150 mg.kg-1）

给药周期2个月结束后

检测视网膜组织中脂质过氧化物丙二醛（MDA）

超氧化物歧化酶（SOD）

谷胱甘肽（GSH）含量

血管内皮生长因子（VEGF）

糖基化产物（AGEs）等指标。结果:与正常组比较

模型组各指标均有明显改变;与模型组比较

羟苯磺酸钙组SOD的活力

VEGF的表达有显著性差异（P<0.05）

但GSH

MDA含量及AGEs的表达差异不明显。结论:本实验2型糖尿病大鼠视网膜病变模型与人类2型糖尿病视网膜病变有很多共性

且能被羟苯磺酸钙所干预

可能为研究2型糖尿病视网膜病变及其防治药物的理想动物模型之一。

Abstract

Objective:Establishment and evaluation of type 2 diabetic retinopathy model in rats

exploring the efffects of calcium dobesilate on the model.Method: SD rats were randomly divided into normal group and model group

model rats with high fat diet for 3 months

then ip STZ（45 mg·kg-1） one times.12 weeks later

the model rats were randomly divided into model group and drug group.Drug group ig daily calcium dobesilate（150 mg·kg-1）.After the administration period

detection of retinal tissue malondialdehyde（MDA）

superoxide dismutase（SOD）

glutathione（GSH）

vascular endothelial growth factor（VEGF）

glycosylated of products（AGEs） and other indicators.Result: Compared with model group

drug group SOD activity

VEGF expression are significantly different（P <0.05）

but GSH

MDA content and the expression of AGEs was not significantly different.Changes of the aboved index proved that the model was successful.Conclusion: The experimental rat model was established successfully.It may provide a perfect animal model for investigating type 2 diabetic retinopathy and pharmacology successful.

关键词

Keywords

references

Views

378

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Application of Puerariae Lobatae Radix in Treatment of Type 2 Diabetes Mellitus： A Review

Modified Buwangsan Ameliorates Cognitive Dysfunction in Rat Model of Type 2 Diabetes Mellitus by Regulating Autophagy in Hippocampus via PI3K/Akt/mTOR Pathway

Sequential Administration of Dihuang Baoyuan Granules and Fuling Yunhua Granules for Teating Type 2 Diabetes Mellitus in Mice

Mechanism of Qingrun Prescription-containing Serum Improving Insulin Resistance in HepG2 Cells via Branched-chain α-keto Acid Dehydrogenase Regulation of Branched-chain Amino Acids （BCAAs）/mTOR Pathway

Related Author

SHI Jing-li

KAN Hong-wei

WANG Hai-qing

LIANG Yan

JIN Kang

YANG Shi-you

LI Liqin

ZENG Zixuan

Related Institution

Key Laboratory of Modern Chinese Medicine Formulations of Jiangxi University of Chinese Medicine， Ministry of Education

School of Pharmacy， Jiangxi University of Chinese Medicine

National Key Laboratory of Creation of Modern Chinese Medicine with Classical Formulas

Dongfang Hospital， Beijing University of Chinese Medicine

Key Laboratory of Health Preservation and Rehabilitation， Ministry of Education， Beijing University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰