The reports concerned with renal injury markers in recent 10 years were consulted through Science Direct database

and literature related to specific markers of renal tubular injury were compiled and analyzed.Some biomarkers have been partially verified the good sensitivity and high specificity in experimental studies and clinical observations.For example

Kidney injury molecule-1

which would over express in the kidney injury in renal tubular epithelial cells

is sensitive to the early diagnosis of kidney cancer

ischemic and renal toxic renal injury

and detected with high stability.Liver-type fatty acid binding protein involved in local lipid metabolism of renal

with high specificity to renal proximal tubule.Its content in urine were of great value for early evaluation of various types of acute kidney injury.As a diagnostic indicator

sensitivity and specificity of Interleukin-18 were more than 90%.It could distinguish acute tubular necrosis from other types of kidney diseases

also predict the renal injury occurrence and renal function recovery.Neutrophil gelatinase-associated lipocalin was often detected as the first expressed product in the injury kidney

which changed earlier than creatinine and other markers

with obvious time advantage.All biomarkers have different characteristics and respective shortage.So joint detection were better to wider and sensitive evaluation of renal injury.