DENG Ya-li1, CHEN Dao-yang2, ZHOU Li-ling3. Application of Microdialysis in Study of Targeting Drug Delivery System and Local Pharmacokinetics[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 264-268.
DENG Ya-li1, CHEN Dao-yang2, ZHOU Li-ling3. Application of Microdialysis in Study of Targeting Drug Delivery System and Local Pharmacokinetics[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 264-268. DOI: 10.13422/j.cnki.syfjx.2011.23.083.
Application of Microdialysis in Study of Targeting Drug Delivery System and Local Pharmacokinetics
摘要
目的:对微透析采样技术研究靶向给药制剂局部药动学文献进行了整理和分析。方法:用Web of Science
Objective:To summarize and analyze the research on application of microdialysis in the study of local pharmacokinetics in targeting drug delivery system.Method: Papers in ISI and CNKI within five years recently are searched.The keywords are microdialysis and local pharmacokinetics.Papers are analyzed and summarized according to the different targeting organs
where the microdialysis is implanted.Result: Microdialysis is widely used for determine local drug concentration in vivo and real time
combined with various analytical techniques
and for assessing local pharmacokinetics in heart
liver
lung
colon
brain
skin
arthrosis
tumor
spinal meninges
cochlea and eyes.Conclusion: Microdialysis provides the opportunity to study targeting drug delivery system in vivo and local pharmacokinetics.