LIU Ming, WANG Hui-sen, LI Geng-sheng. Optimization of Preparation Technology of Qiangxin Capsule by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 47-50.
LIU Ming, WANG Hui-sen, LI Geng-sheng. Optimization of Preparation Technology of Qiangxin Capsule by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 47-50. DOI: 10.13422/j.cnki.syfjx.2012.04.003.
Optimization of Preparation Technology of Qiangxin Capsule by Orthogonal Test
Objective:To optimize preparation process of Qiangxin capsule.Method:Orthogonal experiment and comprehensive scoring method were used to optimize water extraction technology;Forming process and production conditions were studied by multi-factor comparison.Result:Established an HPLC-ELSD method for determination of astragaloside Ⅳ.optimum extraction process was as follows:extracted 3 times with 9 folds the amount of water for 1.5 h each time;Ratio of excipients and optimum wetting agent when making particles of filling material in capsule were determined
relative humidity should be lower than 67%.Conclusion:This preparation process was reasonable and feasible
it could provide theory envidence for industrial production of Qiangxin capsule.
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LIU Ming
WANG Hui-sen
LI Geng-sheng
ZOU Long
LI Huan-huan
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DENG Chang-qing
cao guanghuan
Related Institution
Beijing University of Chinese Medicine
Beijing Key Laboratory of Chinese Materia Pharmacology,Institute of Basic Medical Sciences, Xiyuan Hospital,China Academy of Chinese Medical Sciences
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Hebei Key Laboratory of Traditional Chinese Medicine(TCM) Research on Cardiocerebrovascular Disease,TCM Processing Technology Innovation Center of Hebei Province,College of Pharmacy, Hebei University of Chinese Medicine