Optimization of Preparation Technology of Berberine-β-Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Method

BAI Yan-jie; SUN Guo-xiang; WANG Ping

doi:10.13422/j.cnki.syfjx.2012.04.005

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Optimization of Preparation Technology of Berberine-β-Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Method

更新时间：2024-09-23

- Optimization of Preparation Technology of Berberine-β-Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Method
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 4, Pages: 63-68(2012)
- 作者机构：
  
  沈阳药科大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.04.005
  CLC： TQ461
- Published：2012
- 稿件说明：
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[1]白艳杰,孙国祥,王平.星点设计-效应面法优化小檗碱β-环糊精包合物制备工艺[J].中国实验方剂学杂志,2012,18(04):63-68.

BAI Yan-jie, SUN Guo-xiang, WANG Ping. Optimization of Preparation Technology of Berberine-β-Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 63-68.
[1]白艳杰,孙国祥,王平.星点设计-效应面法优化小檗碱β-环糊精包合物制备工艺[J].中国实验方剂学杂志,2012,18(04):63-68. DOI： 10.13422/j.cnki.syfjx.2012.04.005.

BAI Yan-jie, SUN Guo-xiang, WANG Ping. Optimization of Preparation Technology of Berberine-β-Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 63-68. DOI： 10.13422/j.cnki.syfjx.2012.04.005.

摘要

目的:优化小檗碱-β-环糊精包合物的制备工艺。方法:以小檗碱-β-环糊精包合物的包合率和收率为考察指标

采用星点设计考察包合温度、包合时间以及主客分子投料比对包合工艺的影响

对结果进行多元线性回归、二次多项式和三次多项式拟合

并根据最佳数学模型进行预测。结果:多元线性回归方程的复相关系数较低

三次多项式拟合结果优于二次多项式拟合结果

小檗碱-β-环糊精包合物的最优包合工艺为β-环糊精与小檗碱的投料质量比3.65

包合时间4.5 h

包合温度64℃

包合率和收率预测值与理论值偏差分别为3.28%

2.63%。结论:星点设计-效应面法优化小檗碱β-环糊精包合物制备工艺具有很好的预测性。

Abstract

Objective:To optimize preparation process of berberine-β-cyclodextrin inclusion complex by central composite design and response surface method.Method:With inclusion ratio and yield of berberine-β-cyclodextrin inclusion complex as indexes

influence of inclusion temperature

inclusion time

and ratio of β-CD-berberine to inclusion process was investigated by response surface method

results were fitted by multi-linear equation

second-order and third-order polynomial equation

and optimal inclusion process was predicted according to formulation.Result:Multiple correlation coefficients from multi-linear equation were worse

and multiple correlation coefficients from third-order polynomial equation were prior to second order polynomial equation.Optimum inclusion technology of berberine-β-cyclodextrin inclusion complex were as follows:ratio of β-CD-berberine 3.65∶1

inclusion time 4.5 h

inclusion temperature 64 ℃.Bias of inclusion rate and yield between observed and predicted values were 3.28% and 2.63% respectively.Conclusion:Using central composite design and response surface methodology to optimize preparation of berberine-β-cyclodextrin inclusion complex had good prediction.

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Related Institution

广州中医药大学广东广州510405

Guangzhou of TCM

Shuguang Hospital Affiliated to Shanghai University of TCM

Shaanxi University of Chinese Medicine

The Affiliated Hospital of Shaanxi University of Chinese Medicine

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