Anti-flammatory and Antalgic Effects of Ziziphora clinopodioides and its Acute Toxicity

SHA Ai-long1; CHEN Hong-ling1; MENG Qing-yan2

doi:10.13422/j.cnki.syfjx.2012.04.010

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Anti-flammatory and Antalgic Effects of Ziziphora clinopodioides and its Acute Toxicity

更新时间：2024-09-23

- Anti-flammatory and Antalgic Effects of Ziziphora clinopodioides and its Acute Toxicity
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 4, Pages: 202-204(2012)
- 作者机构：
  
  1. 塔里木大学动物科学学院新疆生产建设兵团塔里木畜牧科技重点实验室
  2. 新疆农业大学农学院
  3. 塔里木盆地生物资源保护利用兵团重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.04.010
  CLC： R29
- Published：2012
- 稿件说明：
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[1]沙爱龙,陈红玲,孟庆艳.维药芳香新塔花水提物的抗炎镇痛作用及其急性毒性[J].中国实验方剂学杂志,2012,18(04):202-204.

SHA Ai-long1, CHEN Hong-ling1, MENG Qing-yan2. Anti-flammatory and Antalgic Effects of Ziziphora clinopodioides and its Acute Toxicity[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 202-204.
[1]沙爱龙,陈红玲,孟庆艳.维药芳香新塔花水提物的抗炎镇痛作用及其急性毒性[J].中国实验方剂学杂志,2012,18(04):202-204. DOI： 10.13422/j.cnki.syfjx.2012.04.010.

SHA Ai-long1, CHEN Hong-ling1, MENG Qing-yan2. Anti-flammatory and Antalgic Effects of Ziziphora clinopodioides and its Acute Toxicity[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 202-204. DOI： 10.13422/j.cnki.syfjx.2012.04.010.

摘要

目的:研究维药芳香新塔花水提物的抗炎、镇痛作用及其急性毒性。方法:小鼠分别ig给予低、中、高剂量（0.5

2 g.kg-1）的芳香新塔花水提物

连续7 d

1次/d。采用二甲苯致小鼠耳廓肿胀及甲醛致小鼠足跖肿胀的方法

观察其抗炎作用;以冰醋酸致小鼠扭体反应

观察其镇痛作用。3组小鼠分别ig给予7.5

30 g.kg-1的芳香新塔花水提物1次

进行急性毒性试验。结果:芳香新塔花水提物0.5

2 g.kg-1对二甲苯致小鼠耳廓肿胀、甲醛致小鼠足肿胀及醋酸致小鼠扭体均有显著抑制作用（P<0.05）;30 g.kg-1及以下剂量单次ig给药后小鼠全部存活

观察期内未见明显毒性反应。结论:芳香新塔花具有明显的抗炎镇痛作用。

Abstract

Objective:To study the anti-inflammatory

antalgic effects and acute toxicity of Ziziphora clinopodioides Lam.Method:The inhibition of auricle edema induced by xylene and paw edema induced by formaldehyde were used to test the anti-inflammation

pain caused by acetic acid in mice was used to evaluate the antalgic effect.Oral administration was used for acute toxicity tests.Result:Z.clinopodioides of low

medium and high dose groups on xylene in rats induced by Auricular swelling

foot swelling in mice induced by formaldehyde and acetic acid twisting had a significant inhibition in mice induced（P<0.05）.All mouse were survived

and no toxic reaction was found in the observed period.Conclusion:Z.clinopodioides has obvious anti-inflammatory and antalgic effects.The clinical dosage of the tablets is within the safty range.

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Related Institution

Heilongjiang Ji Ren Pharmaceutical Co. Ltd.

Biosafety Laboratory，Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences

Institute of Chinese Materia Medica， China Academy of Chinese Medicine Sciences

Sanya Traditional Chinese Medicine Hospital

School of Pharmacy，Xinxiang Medical University

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