Preparation of Dracocephalum moldevica Flavonoids Skeleton-Type Pellets by Extrusion Spheronization Method

LI Yue1; XING Jian-guo2; YANG Xiu1; WANG Xin-chun1; XUE Gui-peng2

doi:10.13422/j.cnki.syfjx.2012.04.017

您当前的位置：

首页 >

文章列表页 >

Preparation of Dracocephalum moldevica Flavonoids Skeleton-Type Pellets by Extrusion Spheronization Method

更新时间：2024-09-23

- Preparation of Dracocephalum moldevica Flavonoids Skeleton-Type Pellets by Extrusion Spheronization Method
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 4, Pages: 1-4(2012)
- 作者机构：
  
  1. 石河子大学药学院
  2. 新疆维吾尔自治区药物研究所
  3. 石河子大学医学院第一附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.04.017
  CLC： R283.6
- Published：2012
- 稿件说明：
移动端阅览
[1]李悦,邢建国,杨秀,王新春,薛桂蓬.挤出滚圆法制备香青兰黄酮骨架型微丸[J].中国实验方剂学杂志,2012,18(04):1-4.

LI Yue1, XING Jian-guo2, YANG Xiu1, et al. Preparation of Dracocephalum moldevica Flavonoids Skeleton-Type Pellets by Extrusion Spheronization Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 1-4.
[1]李悦,邢建国,杨秀,王新春,薛桂蓬.挤出滚圆法制备香青兰黄酮骨架型微丸[J].中国实验方剂学杂志,2012,18(04):1-4. DOI： 10.13422/j.cnki.syfjx.2012.04.017.

LI Yue1, XING Jian-guo2, YANG Xiu1, et al. Preparation of Dracocephalum moldevica Flavonoids Skeleton-Type Pellets by Extrusion Spheronization Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 1-4. DOI： 10.13422/j.cnki.syfjx.2012.04.017.

摘要

目的:优化挤出滚圆法制备维药香青兰黄酮骨架微丸的制备工艺。方法:用挤出滚圆法制备香青兰黄酮骨架微丸;采用单因素考察和正交设计筛选最优处方和工艺条件;考察微丸的粉体学性质和体外释放度。结果:采用挤出滚圆法制备的香青兰黄酮骨架微丸圆整度、流动性及堆密度均较好

成品收率高

且30 min内体外释放度均达到80%以上。结论:挤出滚圆法制备维药香青兰黄酮骨架微丸

工艺简便易行

制得的微丸质量好

收率高。

Abstract

Objective:To optimize preparation technology of Dracocephalum moldevica flavonoids skeleton-type pellets by extrusion spheronization method.Method:D.moldevica flavonoids skeleton-type pellets were prepared by extrusion spheronization method;Optimal formulation and process was obtained by single factor test and orthogonal design;Micromeritic properties and cumulative in vitro release of pellets were determined.Result:D.moldevica flavonoids skeleton-type pellets were prepared by extrusion spheronization method were all good of roundness

fluidity and density

product yield was high

in vitro release reached more than 80% in 30 min.Conclusion:D.moldevica flavonoids skeleton-type pellets were prepared by extrusion spheronization method

this preparation process was simple and feasible

quality of prepared pellets was excellent and product yield was high.

关键词

Keywords

references

Views

343

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Optimization on Preparation Process of Total Flavonoids from -phospholipids Complex by Central Composite Design and Response Surface Methodology

Preparation and Properties Investigation of Gardenia Extract Pellet by Extrusion-Spheronization Method

Related Author

XUE Gui-peng

WANG Xin-chun

YANG Xiu

XING Jian-guo

LI Yue

WU Huang-yan

YIN Xing-bin

QU Chang-hai

Related Institution

College of Chinese Materia Medica,Beijing University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰