Optimization and Preliminary Evaluation of Self Microemulsifying Formulation of Wolfberry Seed Oil

MA Yan-ni1; WANG Han-qing1; WANG Wen-ping1; LIU Hong-tao1; LIU Meng1

doi:10.13422/j.cnki.syfjx.2012.04.023

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Optimization and Preliminary Evaluation of Self Microemulsifying Formulation of Wolfberry Seed Oil

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- Optimization and Preliminary Evaluation of Self Microemulsifying Formulation of Wolfberry Seed Oil
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 4, Pages: 28-31(2012)
- 作者机构：
  
  1. 宁夏医科大学药学院
  2. 宁夏回药现代化工程技术研究中心
  3. 宁夏医科大学宁夏医药研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.04.023
  CLC： R283
- Published：2012
- 稿件说明：
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[1]马妍妮,王汉卿,王文苹,刘红涛,刘萌.枸杞籽油自微乳化处方筛选与初步评价[J].中国实验方剂学杂志,2012,18(04):28-31.

MA Yan-ni1, WANG Han-qing1, WANG Wen-ping1, et al. Optimization and Preliminary Evaluation of Self Microemulsifying Formulation of Wolfberry Seed Oil[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 28-31.
[1]马妍妮,王汉卿,王文苹,刘红涛,刘萌.枸杞籽油自微乳化处方筛选与初步评价[J].中国实验方剂学杂志,2012,18(04):28-31. DOI： 10.13422/j.cnki.syfjx.2012.04.023.

MA Yan-ni1, WANG Han-qing1, WANG Wen-ping1, et al. Optimization and Preliminary Evaluation of Self Microemulsifying Formulation of Wolfberry Seed Oil[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 28-31. DOI： 10.13422/j.cnki.syfjx.2012.04.023.

摘要

目的:优选枸杞籽油自微乳制剂处方

并对其进行初步评价。方法:采用加水滴定法制备伪三元相图

优选表面活性剂及油相种类;通过比较体系透光性确定处方各组分比例

考察处方自乳化时间及其在离心、冷冻、加热等条件下的稳定性。结果:最佳枸杞籽油自微乳化处方为油酸乙酯-聚山梨醇酯80-枸杞籽油2∶7∶1;该处方能在10 min内自发形成具乳光透明乳液、粒径小而均匀

其动力学稳定性良好但对高温较敏感。结论:所得枸杞籽油自微乳处方乳化性能良好

较稳定。

Abstract

Objective:To optimize self microemulsion formulation of Wolfberry seed oil and to preliminary evaluate its performance in vitro.Method:Kind of surfactant and oil phase were optimized with pseudo ternary phase diagram was prepared by water titration method;Proportion of each component from prescription were determined by comparing transmittance of system

self emulsifization time of formulation and its stability under several conditions（centrifugation

freezing

heating and other conditions） were evaluated.Result:Optimum formulation of Wolfberry seed oil was composed of 10% Wolfberry seed oil

20% ethylise oleas and 70% Tween 80.This formulation took less than 10 minutes to form spontaneously to be opalescent transparent latex with small and uniform particle size

it showed good stability of kinetic

but sensitive to heat.Conclusion:Optimum formulation of Wolfberry seed oil showed good self emulsification performance and acceptable stability.

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