ZHOU Feng, ZHANG Hong-chi, LIU Rui, et al. Isolation and Biological Evaluation of Secondary Metabolites of Endophytic Fungus Aspergillus sp.from Astragalus membranaceus[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 125-128.
ZHOU Feng, ZHANG Hong-chi, LIU Rui, et al. Isolation and Biological Evaluation of Secondary Metabolites of Endophytic Fungus Aspergillus sp.from Astragalus membranaceus[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 125-128. DOI: 10.13422/j.cnki.syfjx.2012.04.043.
Isolation and Biological Evaluation of Secondary Metabolites of Endophytic Fungus Aspergillus sp.from Astragalus membranaceus
Objective:To study on secondary metabolites from an endophytic fungus of Astragalus membranaceus.Method:The compounds were isolated by column chromatography and identified on the basis of physic-chemical constants and spectral analysis.Result:Six compounds were obtained and elucidated as cerevisterol(1)
ergosterol peroxide(2)
fumitremorgin B(3)
verruculogen(4)
fumitremorgin C(5) and cyclotryprostatins B(6).Biological evaluation showed that the compounds displayed significantly inhibitory activities.Especially
compound 6 had strong antifungal activity.Conclusion:The six compounds were obtained from an endophytic fungus Aspergillus sp.of A.membranaceus for the first time.