Absorption Kinetics of Gastrodin and Paeonol of Tiangou Jangya Capsules in Rats’ Intestinal

ZHANG Wei; LI Ling-jun; WANG Ying-lan

doi:10.13422/j.cnki.syfjx.2012.04.050

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Absorption Kinetics of Gastrodin and Paeonol of Tiangou Jangya Capsules in Rats’ Intestinal

更新时间：2024-09-23

- Absorption Kinetics of Gastrodin and Paeonol of Tiangou Jangya Capsules in Rats’ Intestinal
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 4, Pages: 150-153(2012)
- 作者机构：
  
  山东中医药大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.04.050
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]张微,李凌军,王瑛兰.天钩降压胶囊中天麻苷、丹皮酚在大鼠离体小肠的吸收动力学[J].中国实验方剂学杂志,2012,18(04):150-153.

ZHANG Wei, LI Ling-jun, WANG Ying-lan. Absorption Kinetics of Gastrodin and Paeonol of Tiangou Jangya Capsules in Rats’ Intestinal[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 150-153.
[1]张微,李凌军,王瑛兰.天钩降压胶囊中天麻苷、丹皮酚在大鼠离体小肠的吸收动力学[J].中国实验方剂学杂志,2012,18(04):150-153. DOI： 10.13422/j.cnki.syfjx.2012.04.050.

ZHANG Wei, LI Ling-jun, WANG Ying-lan. Absorption Kinetics of Gastrodin and Paeonol of Tiangou Jangya Capsules in Rats’ Intestinal[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 150-153. DOI： 10.13422/j.cnki.syfjx.2012.04.050.

摘要

目的:研究天钩降压胶囊中有效成分的大鼠离体小肠吸收动力学。方法:采用外翻肠囊法

用HPLC测定不同取样时间肠内液天麻苷、丹皮酚的含量

计算累计吸收量

以天麻苷、丹皮酚的累计吸收量对时间作线性回归分析

计算吸收动力学参数。结果:天麻苷回归方程为Y=0.000 6X-0.012 8（r=0.993 0）

Ka=6.0×10-5μg.min-1.cm-2

t1/2=1.16×104h;丹皮酚回归方程为Y=0.000 68X+0.001 1（r=0.983 5）

Ka=6.8×10-5μg.min-1.cm-2

t1/2=1.02×104 h。结论:天钩降压胶囊中天麻苷、丹皮酚在大鼠离体小肠的吸收为一级动力学过程。

Abstract

Objective:To study the absorption kinetics of the active components of Tiangou Jangya capsules in rats’ intestinal.Method:Using an improved rat everted gut sac model

gastrodin concentration and paeonol concentration were determined by HPLC.The concentration of cumulative absorption was calculated.The linear regression equation was figured through the concentration of cumulative absorption and time.The parameters were calculated.Result:The regression equation of gastrodin was Y=0.000 6X-0.012 8（r=0.993 0）

Ka=6.0×10-5 μg·min-1·cm-2

t1/2=1.16×104 h;the regression equation of paeonol was Y=0.000 68X+0.001 1（r=0.983 5）

Ka=6.8×10-5 μg·min-1·cm-2

t1/2=1.02×104 h.Conclusion:The absorption of gastrodin and paeonol conforms to the first-order kinetics in rats’intestinal.

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