Diuetic Effects of Guiling Shenzhu Decoction and its Different Effective Parts

WU Yan1; OUYANG Zhen1; ZHAO Ming1; YANG Xi-hui1; YANG Bing1; WANG Qing-qing1

doi:10.13422/j.cnki.syfjx.2012.04.055

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Diuetic Effects of Guiling Shenzhu Decoction and its Different Effective Parts

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- Diuetic Effects of Guiling Shenzhu Decoction and its Different Effective Parts
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 4, Pages: 169-172(2012)
- 作者机构：
  
  1. 江苏大学药学院
  2. 江苏大学附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.04.055
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]吴燕,欧阳臻,赵明,杨锡辉,杨兵,王庆庆.桂苓神术汤及其有效部位的利尿作用[J].中国实验方剂学杂志,2012,18(04):169-172.

WU Yan1, OUYANG Zhen1, ZHAO Ming1, et al. Diuetic Effects of Guiling Shenzhu Decoction and its Different Effective Parts[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 169-172.
[1]吴燕,欧阳臻,赵明,杨锡辉,杨兵,王庆庆.桂苓神术汤及其有效部位的利尿作用[J].中国实验方剂学杂志,2012,18(04):169-172. DOI： 10.13422/j.cnki.syfjx.2012.04.055.

WU Yan1, OUYANG Zhen1, ZHAO Ming1, et al. Diuetic Effects of Guiling Shenzhu Decoction and its Different Effective Parts[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 169-172. DOI： 10.13422/j.cnki.syfjx.2012.04.055.

摘要

目的:研究桂苓神术汤的利尿作用

筛选利尿作用的有效部位并探讨其作用机制。方法:SD大鼠

随机分为18组:正常组、模型组

呋噻米组

桂苓神术汤及石油醚部位、乙酸乙酯部位、正丁醇部位、剩余部位分别设10.0

5.0

2.5 g.kg-1 3个剂量组。每组大鼠均按40 mL.kg-1生理盐水ig

形成盐水负荷模型。45 min后

ig给予不同剂量的桂苓神术汤及不同极性部位

用大鼠代谢笼法观察大鼠6 h的尿量

并测定尿液pH及Na+

K+

Cl-的浓度。结果:桂苓神术汤组（5.0

2.5 g.kg-1）

乙酸乙酯部位组（5.0 g.kg-1）

剩余部位组（5.0 g.kg-1）均能显著增加盐水负荷大鼠6 h的尿量;尿中K+排出量较模型组均显著升高

分别为（850.3±78.8）

（816.6±91.1）

（826.3±84.9）

（776.7±69.1）mmol.L-1

Na+

Cl-排出量较模型组无显著差异。结论:桂苓神术汤及有效部位具有缓和持久的利尿作用

其利尿作用机制可能为增加大鼠尿液中K+的排泄。

Abstract

Objective:To study the diuetic effects and its mechanism of Guiling Shenzhu decoction and its different effective parts.Method:The effect on urinre volum and urinary electrolyte（Na+

K+

Cl-） were assessed by using rat metabolic cage and electrolyte analyzer following oral administration of Guiling Shenzhu decoction（10.0

5.0

2.5 g·kg-1） and its different polar fractions（10

5.0

2.5 g·kg-1）.Result:Guiling Shenzhu decoction（5.0

2.5 g·kg-1） and extraction of ethyl acetate（5.0 g·kg-1） and residual water layer（5.0 g·kg-1） had good diuretic effect.The urine K+ excretion increased significantly

but Na+ and Cl-excretion did not increase.Conclusion:Guiling Shenzhu decoction and extraction of ethyl acetate and residual water layer have significant and persistent diuretic effect.They cause marked increase in urinary K+level and it may be the diuetic mechanism.

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