Effect of Xiangsi Tengcha on Dispelling Alcoholic Intoxication

WU Ka; CHEN Hong-xia; HUANG Ren-bin; JIAO Yang

doi:10.13422/j.cnki.syfjx.2012.04.060

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Effect of Xiangsi Tengcha on Dispelling Alcoholic Intoxication

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- Effect of Xiangsi Tengcha on Dispelling Alcoholic Intoxication
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 4, Pages: 187-189(2012)
- 作者机构：
  
  广西医科大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.04.060
  CLC： R285.5
- Published：2012
- 稿件说明：
移动端阅览
[1]吴咖,陈红霞,黄仁彬,焦杨.相思藤茶水提物的解酒作用[J].中国实验方剂学杂志,2012,18(04):187-189.

WU Ka, CHEN Hong-xia, HUANG Ren-bin, et al. Effect of Xiangsi Tengcha on Dispelling Alcoholic Intoxication[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 187-189.
[1]吴咖,陈红霞,黄仁彬,焦杨.相思藤茶水提物的解酒作用[J].中国实验方剂学杂志,2012,18(04):187-189. DOI： 10.13422/j.cnki.syfjx.2012.04.060.

WU Ka, CHEN Hong-xia, HUANG Ren-bin, et al. Effect of Xiangsi Tengcha on Dispelling Alcoholic Intoxication[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 187-189. DOI： 10.13422/j.cnki.syfjx.2012.04.060.

摘要

目的:研究相思藤茶水提物（Xiangsi Tengcha

XSTC）的解酒作用及其机制。方法:分别给予小鼠高、中、低剂量的XSTC（16

4 g.kg-1）、海王金樽片（1.5 g.kg-1）和生理盐水

连续6 d。第6天药后30 min

每20 min给予一定剂量白酒1次

直至动物死亡。观察醉酒（翻正反射消失）潜伏期、醉酒时白酒摄入量、死亡时间和死亡时白酒摄入量

并测定小鼠肝脏中天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、超氧化物歧化酶（SOD）、乙醇脱氢酶（ADH）、乙醛脱氢酶（ALDH）的活力以及丙二醛（MDA）的含量。结果:在给予白酒前预先给予XSTC处理

小鼠醉酒潜伏期延长

肝脏中ALT

AST的活性和MDA的含量降低

ADH

ALDH和SOD的活性升高（P<0.05）。结论:XSTC可能通过提高ADH

ALDH

SOD的活性

降低MDA的含量

减轻乙醇对肝脏的损害

有一定的解酒作用。

Abstract

Objective:To study the anti-alcohol effecty of Xiangsi Tengcha（XSTC）.Method:Before alcoholism

mouse were given XSTC（16

4 g·kg-1）

haiwang jinzun tablets（HWJZT 1.5 g·kg-1） and saline for six days.After 30 minutes of the last administration

the mouse were given with 56% alcohol every 20 minutes until they died.The drunk（righting areflexia） incubation period

dose of alcohol intake

time of death and lethal dose of alcohol were recorded.The activity of AST

ALT

ADH

ALDH

SOD and the content of MDA were determined.Result:The incubation period of drunkenness was extended significantly.The activity of ADH

ALDH and SOD were increased and the activity of ALT

AST and the content of MDA were decreased（P<0.05）.Conclusion:XSTC could prevent drunkenness caused by strengthened the activity of ADH

ALDH and SOD.

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