REN Shou-zhong1, GUO Jian-sheng1, LI-Xin1, et al. Effect of Anwei Pill on Inflammatory Cytokines of Serum and Expression of NF-kappa B of Gastric Mucosa in Chronic Gastritis Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 198-201.
REN Shou-zhong1, GUO Jian-sheng1, LI-Xin1, et al. Effect of Anwei Pill on Inflammatory Cytokines of Serum and Expression of NF-kappa B of Gastric Mucosa in Chronic Gastritis Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 198-201. DOI: 10.13422/j.cnki.syfjx.2012.04.063.
Effect of Anwei Pill on Inflammatory Cytokines of Serum and Expression of NF-kappa B of Gastric Mucosa in Chronic Gastritis Rats
Objective:To exploe effect of Anwei pill on inflammatory cytokines of serum and the expression of nelclear factor-kappa B(NF-κB) p65 mRNA on gastric mucosa in chronic gastritis rats rats.Method:Rats chronic gastritis model was established by combined administration of 60% ethanol
20 mmol·L-1sodium deoxycholate and 0.05% ammonia water.Aanwei pills was given for 30 day.Levels of interleukin(IL-2)
(IL-4)
tumor necrosis factor-α(TNF-α) in serum were measured by enzyme-linked immunosorbent assay(ELISA).The expression of NF-κB p65 mRNA in gastric mucosa was detected in situ hybridization.Result:The concentration of IL-4 and IL-2 in Anwei pill group was increased and decreased compared with model group
respectively.TNF-α was decreased.Anwei pill could decrease expression of NF-κB p65 mRNA in gastric mucosa.Conclusion:Anwei pill can protect gastric mucosa and inhibit the inflammation reaction.Its mechanism is probably associated with inhibition of the expression of NF-κB p65 mRNA and regulation of immunity.