Mechanism on Treatment of Metrorrhagia due to Blood-Heat by Kangyan Gongle Capsule

WU Xiao-fei; JIN Cui-ying; ZHOU Jian-ping; WANG Zhi-bin

doi:10.13422/j.cnki.syfjx.2012.04.064

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Mechanism on Treatment of Metrorrhagia due to Blood-Heat by Kangyan Gongle Capsule

更新时间：2024-09-23

- Mechanism on Treatment of Metrorrhagia due to Blood-Heat by Kangyan Gongle Capsule
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 4, Pages: 205-209(2012)
- 作者机构：
  
  北京市药品检验所药物安全评价中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.04.064
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]吴虓飞,金翠英,周建平,王志斌.抗炎宫乐胶囊治疗血热型崩漏的机制[J].中国实验方剂学杂志,2012,18(04):205-209.

WU Xiao-fei, JIN Cui-ying, ZHOU Jian-ping, et al. Mechanism on Treatment of Metrorrhagia due to Blood-Heat by Kangyan Gongle Capsule[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 205-209.
[1]吴虓飞,金翠英,周建平,王志斌.抗炎宫乐胶囊治疗血热型崩漏的机制[J].中国实验方剂学杂志,2012,18(04):205-209. DOI： 10.13422/j.cnki.syfjx.2012.04.064.

WU Xiao-fei, JIN Cui-ying, ZHOU Jian-ping, et al. Mechanism on Treatment of Metrorrhagia due to Blood-Heat by Kangyan Gongle Capsule[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 205-209. DOI： 10.13422/j.cnki.syfjx.2012.04.064.

摘要

目的:探讨抗炎宫乐胶囊治疗血热型崩漏的机制。方法:雌性ICR小鼠按体重随机分为模型组、空白组、抗炎宫乐胶囊高、中、低（1.2

0.6

0.3 g.kg-1）剂量组、宫血宁组、布洛芬组

分别ig给药5

10 d。雌性SD大鼠分组情况同小鼠

抗炎宫乐胶囊高、中、低（0.94

0.47

0.24 g.kg-1）剂量组

ig给药20

30 d。通过测定抗炎宫乐胶囊对断尾出血时间、血液流变学指标、血小板聚集功能、抗炎镇痛、促性腺激素和性激素调节的影响

研究其治疗血热型崩漏的机制。结果:抗炎宫乐胶囊能够明显缩短小鼠断尾出血时间（P<0.05）;缩短大鼠血浆凝血酶原时间（PT）和凝血活酶时间（APTT）（P<0.05）

增强二磷酸腺苷（ADP）诱导大鼠血小板聚集功能（P<0.05）;减小二甲苯所致小鼠耳肿胀度（P<0.05）和子宫异物埋植所致大鼠子宫肿胀度（P<0.05）;延长小鼠疼痛扭体的潜伏期和减少疼痛扭体的次数（P<0.05）;提高去卵巢大鼠血清中卵泡刺激素（P<0.05）、黄体生成素（P<0.05）、雌二醇水平（P<0.05）和降低血清中孕酮水平（P<0.05）。结论:抗炎宫乐胶囊对模型动物具有明显的止血、抗炎、镇痛和调节下丘脑-垂体-性腺轴的作用

其治疗血热型崩漏的作用及机制可能与上述环节有关。

Abstract

Objective:To study the mechanism on treatment of metrorrhagia due to blood-heat by Kangyan Gongle capsule.Method:Female ICR mouse were randomized into model group

control group

Kangyan Gongle capsule groups treated with dose of 1.2

0.6

0.3 g·kg-1

Gongxuening group and Ibuprofen group

treatment lasted 5

10 and 10 days

respectively.Female SD rats were randomized into the groups as the above mentioned.The dose of Kangyan Gongle capsule was 0.94

0.47

0.24 g·kg-1 accordingly.The treatments（ig） lasted 20

30 days

respectively.Bleeding time

hemorheology

platelet aggregation rate

regulating gonadotrophin and gonadal hormone

anti-inflammatory and analgesic effect were determined to study the mechanism.Result:Kangyan Gongle capsule could obviously shorten the bleeding time of mice broken tail（P<0.05）

shorten prothrombin time（PT） and activated partial thromboplastin time（APTT）（P<0.05）

enhance platelet aggregation rate（P<0.05）

decrease the degree of mice ear edema caused by xylene（P<0.05） and rat uterus swelling by embedded foreign matter（P<0.05）

relieve mice’ pain caused by oxytocin（P<0.05）

upregulate the level of follide stimulating hormone（FSH）（P<0.05）

luteinizing hormone（LH）（P<0.05）

estradiol（E2）（P<0.05） and downregulate the level of P（P<0.05） in ovariectomized rat’ serum.Conclusion:Kangyan Gongle capsule obviously indicates hemostatic

antiinflammatory

analgesic effect and could regulate the function of hypothalamus-pituitary-gonad axis

which.May be included into the mechanism of actions.

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WANG Zhi-bin

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Related Institution

State Key Laboratory of Bioactive Substances and Function of Natural Medicine，Institute of Materia Medica， Chinese Academy of Medical Sciences and Peking Union Medical College

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Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization， National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine，Nanjing University of Chinese Medicine

Chengdu Fifth People's Hospital Chengdu

Sichuan Academy of Medical Sciences, Sichuan People's Hospital

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