SUN Yu-hua, Hamulati, XU Lei, et al. Pharmocodynamics Study of Jiangzhi Granule[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 215-218.
SUN Yu-hua, Hamulati, XU Lei, et al. Pharmocodynamics Study of Jiangzhi Granule[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 215-218. DOI: 10.13422/j.cnki.syfjx.2012.04.065.
Objective:To study the effect of Jiangzhi granule(JZG) on hyperlipemia models.Method:Hyperlipemia models were established in mice
rat and quails.All animals were randomly divided into normal group
model group
xuezhikang group
JZG high
middle and low dose group.The dosage for mice
rat and quails was 10.0
5.0
2.5 g·kg-1
8.0
4.0
2.0 g·kg-1 and 8.0
4.0
2.0 g·kg-1
respectively Administration course was one week for mouse
four weeks for rats and 12 weeks for quails.The content of cholestero(CHO)
triglyceride(TG)
high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterd(LDL-C) in serum was determined after administration The atherosclerotic plaque in quail hyperlipemia models was exmined by histopathologic examination.Result:The content of CHO
TG
LDL-C in serum of mice
rats and quails was decreased remarkedly.The decrease of HDL-C/CHO index was reversed.Atheroselerotic plaque in quail lightened obviously.No change of HDL-C and VLDL-C were not found.Conclusion:JZG can effectively decrease the serum lipid and prevent the formation of atherosclerosis.
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Related Author
SUN Yu-hua
Hamulati
XU Lei
HU Meng-ying
PANG Shi-bin
LIU Xiao-yan
ZHANG Lan-lan
Bin HU
Related Institution
Key Laboratory of Chinese Materia Medica under Ministry of Education, Heilongjiang Key Laboratory of Traditional Chinese Medicine and Natural Medicine Pharmacodynamic Material Bases, Heilongjiang University of Chinese Medicine
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University
Chengdu University of Traditional Chinese Medicine(TCM)