Objective:To observe the effects of Zhuangshen Yihao granule on proteinuria excreting in nephrosis rats induced by adriamycin（ADR）

and discuss the mechanism in biochemistry and molecular biology.Method:The proteinuria model of nephrosis rats was established by injecting ADR（0.006 g·kg-1） by the tail vein.And then they were randomly divided into groups as follows:model group

lotensin group（0.003 g·kg-1）

low-dose group（2.52 g·kg-1） and high-dose group（10.08 g·kg-1） of Zhuangshen Yihao granule

and normal group was set up meanwhile

drugs were given accordingly once a day after 7 days of modeling

administration lasted 8 weeks.At the 8th week of he experiment

24 hours urinary protein was assayed

urine β2-MG and tumor necrosis factor（TNF）-αin blood serum were detected by radioimmunoassay.Result:Levels of 24 hours urinary protein

urine β2-MG and the content of TNF-α of serum in lotensin group

the low-dose and the high-dose groups of Zhuangshen Yihao granule were reduced

especially in the high-dose group of Zhuangshen Yihao granule（P<0.05）.Conclusion:Zhuangshen Yihao granule can exerted a protective effect on glomerulus and renal tubule

and revealed that producing an effect on the regulation network of cytokines

and abating inflammatory reaction may be its possible mechanism.Furthermore

the above curative effects of Zhuangshen Yihao granule in the high-dose group were better than in the low-dose group and the lotensin group.