Effect of Baoji Wan Powder on Diarrhea and Bowel Movement in Mice

RU Li; GUO Qi-yue; XU Chang-hui

doi:10.13422/j.cnki.syfjx.2012.04.070

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Effect of Baoji Wan Powder on Diarrhea and Bowel Movement in Mice

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- Effect of Baoji Wan Powder on Diarrhea and Bowel Movement in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 4, Pages: 235-237(2012)
- 作者机构：
  
  广州中医药大学科技产业园
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.04.070
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]茹丽,郭起岳,许常辉.保济丸粉对小鼠腹泻及肠运动的影响[J].中国实验方剂学杂志,2012,18(04):235-237.

RU Li, GUO Qi-yue, XU Chang-hui. Effect of Baoji Wan Powder on Diarrhea and Bowel Movement in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 235-237.
[1]茹丽,郭起岳,许常辉.保济丸粉对小鼠腹泻及肠运动的影响[J].中国实验方剂学杂志,2012,18(04):235-237. DOI： 10.13422/j.cnki.syfjx.2012.04.070.

RU Li, GUO Qi-yue, XU Chang-hui. Effect of Baoji Wan Powder on Diarrhea and Bowel Movement in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 235-237. DOI： 10.13422/j.cnki.syfjx.2012.04.070.

摘要

目的:观察保济丸粉辐照前后对小鼠的腹泻及肠运动的影响。方法:采用蓖麻油致小鼠腹泻模型

观察辐射前后保济丸粉的止泻作用;采用溴吡斯的明致小鼠肠运动亢进模型观察对炭末推进的影响

观察对小鼠不同肠段水分吸收的影响。以上实验辐照前后保济丸粉剂量均为给生药1.3

2.6

5.2 g.kg-1

连续3 d。结果:保济丸粉辐照前后可显著延长蓖麻油致小鼠腹泻的起始时间（开始排湿粪时间）

显著减少腹泻次数（排泄湿粪次数）

与模型对照组比较

P<0.01;可显著抑制溴吡斯的明所致小鼠小肠运动亢进作用

与模型对照组比较

P<0.01或P<0.05;可显著减少小鼠大肠与小肠水分含量

与正常对照组比较

P<0.01或P<0.05。结论:保济丸粉辐照前后均可止泻和抑制肠运动

其止泻作用可能是通过抑制肠运动及减少小鼠肠腔内水分所致。保济丸粉辐照前后的作用比较

差异无显著性。

Abstract

Objective:To observe effect of Baoji Wan powder on diarrhea and intestinal motility induced by irradiation in mice.Method:Using castor oil induced diarrhea model

we observed Baoji Wan powder’s（before and after irradiation） antidiarrheal effect at doses of 1.3

2.6

5.2 g·kg-1ig for 3 d in mice.Using pyridostigmine bromide induced hyperthyroidism intestine movement in mice

the effect of Baoji Wan powder on intestine movements was observed.Result:Baoji Wan powder before and after irradiation could significantly extend the castor oil-induced small diarrhea

the starting time of diarrbea（indicated by watery feces）

the number of diarrhea

compared with the control group（P<0.01）.The powder could significantly inhibit pyridostigmine bromide-induced intestinal motility compared with that in the model group（P<0.01

P<0.05）;and it could significantly reduce the water content in colon and small intestine

compared with that in normal control group（P<0.01

P<0.05）.Conclusion:Baoji Wan powder before and after irradiation has the effect of inhibiton of diarrhea and suppression of bowel movement

the antidiarrheal effect may be gained by inhibition of bowel movements and reduce of water in intestine.Before and after irradiation

Baoji Wan powder’s difference in effects was not significant.

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Related Author

RU Li

GUO Qi-yue

XU Chang-hui

LI Zhe

LI Na

CUI Xiaoyan

ZHAO-LAN Qingqing

YU Yongzhou

Related Institution

Institute of Basic Medicine， Chengde Medical University

Hebei Institute for Drug and Medical Device Control

Hebei Key Laboratory of Nerve Injury and Repair， Chengde Medical University

Hebei Province Key Laboratory of Study and Exploitation of Chinese Medicine， Chengde Medical College

College of Biology and Food Engineering，Chongqing Three Gorges University

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