Optimization of Prescription for Colon-targeted Tablets with Total Flavonoids from Euphorbia humifusa（EFCTT） by Central Composite Design-response Surface Method

ZHAO Ming-qin; YIN Rong-li; BAI Lan; LI Dong-fen; LV Yi-ping; LI Jie

doi:10.13422/j.cnki.syfjx.2012.08.011

您当前的位置：

首页 >

文章列表页 >

Optimization of Prescription for Colon-targeted Tablets with Total Flavonoids from Euphorbia humifusa（EFCTT） by Central Composite Design-response Surface Method

更新时间：2024-09-23

- Optimization of Prescription for Colon-targeted Tablets with Total Flavonoids from Euphorbia humifusa（EFCTT） by Central Composite Design-response Surface Method
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 8, Pages: 42-45(2012)
- 作者机构：
  
  成都中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.08.011
  CLC： TQ461
- Published：2012
- 稿件说明：
移动端阅览
[1]赵明琴,尹蓉莉,白兰,李东芬,吕懿平,李杰.星点设计-效应面法优化地锦草总黄酮结肠定位片处方[J].中国实验方剂学杂志,2012,18(08):42-45.

ZHAO Ming-qin, YIN Rong-li, BAI Lan, et al. Optimization of Prescription for Colon-targeted Tablets with Total Flavonoids from Euphorbia humifusa（EFCTT） by Central Composite Design-response Surface Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 42-45.
[1]赵明琴,尹蓉莉,白兰,李东芬,吕懿平,李杰.星点设计-效应面法优化地锦草总黄酮结肠定位片处方[J].中国实验方剂学杂志,2012,18(08):42-45. DOI： 10.13422/j.cnki.syfjx.2012.08.011.

ZHAO Ming-qin, YIN Rong-li, BAI Lan, et al. Optimization of Prescription for Colon-targeted Tablets with Total Flavonoids from Euphorbia humifusa（EFCTT） by Central Composite Design-response Surface Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 42-45. DOI： 10.13422/j.cnki.syfjx.2012.08.011.

摘要

目的:应用星点设计-效应面法优化地锦草总黄酮结肠定位片的处方。方法:以果胶、L-HPC用量及包衣增重为考察因素

以2

9 h地锦草总黄酮中有效成分槲皮素的累积释放度为评价指标

采用Design-expert软件对试验数据进行多元线性模型和二次多项式模型拟合

得出最佳数学模型

绘制效应图和等高线图

通过重叠等高线图得到最优处方并进行验证。结果:二次多项式模型相关系数优于多元线性模型

为最终拟合模型;最佳处方的各时间点累计释放度的实际值和预测值接近

相对偏差绝对值<5%。结论:通过星点设计-效应面法建立的模型预测性良好

可用于对地锦草总黄酮结肠定位片处方的优化。

Abstract

Objective:To optimize formulations of total flavonoids from Euphorbia humifusa（EFCTT） by central composite design-response surface method.Method: With the amount of lactose and L-HPC

coating weight gain as factors

with cumulative release at 2

9 h of quercetin from total flavonoids as index

Design-Expert software was used to fit multivariate linear models and quadratic multinomial models for experimental data

and obtained optimum mathematical model

drew effect diagram and contour maps

optimum prescription was obtained by overlapping contour maps and verified.Result: The correlation coefficient of quadratic multinomial models was better than multivariate linear models

and it was the final fitting model;Cumulative release in four time point of optimum prescription was close between observed value and predicted value with relative deviation was less than 5%.Conclusion: Model established by central composite design-response surface method had good predictive

it could be used to optimize prescription of EFCTT.

关键词

Keywords

references

Views

142

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Optimization of Streamed Processing Technology of Dendrobii Caulis with Wine by Central Composite Design-Response Surface Methodology

Optimization of Prescription of Lycii Fructus Polysaccharide Buccal Tablets by Central Composite Design-response Surface Methodology and Investigation of Its Immunomodulatory Effect

Optimization of Formulation of Co-loaded Docetaxel and Gambogic Acid Albumin Nanoparticles and Evaluation of Its Quality

Quantitative and Fingerprint of Ilex pubescens Slices

Related Author

ZHAO Ming-qin

YIN Rong-li

BAI Lan

LI Dong-fen

LV Yi-ping

Li Jie

OU De-ming

ZHOU Yi-fan

Related Institution

Heilongjiang University of Chinese Medicine

Pharmacy College, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province, Key Laboratory Breeding Base of Co-founded by Sichuan Province and Ministry of Science and Technology

Kaili University

Jilin Agricultural University

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰