Release Mechanism of PNS Microporous Membrane Osmotic Pump Tablets

XU Xiao-hong; LIAO Li-yun; JIANG Ting

doi:10.13422/j.cnki.syfjx.2012.08.031

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Release Mechanism of PNS Microporous Membrane Osmotic Pump Tablets

更新时间：2024-09-23

- Release Mechanism of PNS Microporous Membrane Osmotic Pump Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 8, Pages: 12-14(2012)
- 作者机构：
  
  成都医学院药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.08.031
  CLC： R283
- Published：2012
- 稿件说明：
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[1]许小红,廖丽云,蒋婷.三七总皂苷微孔渗透泵片释药机制[J].中国实验方剂学杂志,2012,18(08):12-14.

XU Xiao-hong, LIAO Li-yun, JIANG Ting. Release Mechanism of PNS Microporous Membrane Osmotic Pump Tablets[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 12-14.
[1]许小红,廖丽云,蒋婷.三七总皂苷微孔渗透泵片释药机制[J].中国实验方剂学杂志,2012,18(08):12-14. DOI： 10.13422/j.cnki.syfjx.2012.08.031.

XU Xiao-hong, LIAO Li-yun, JIANG Ting. Release Mechanism of PNS Microporous Membrane Osmotic Pump Tablets[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 12-14. DOI： 10.13422/j.cnki.syfjx.2012.08.031.

摘要

目的:研究三七总皂苷微孔渗透泵片的释药机制。方法:通过考察三七总皂苷微孔渗透泵片在不同渗透压介质中的释放行为及不同释放方法对药物释放速率的影响

探讨该制剂释放机制。结果:随着包衣膜内外渗透压差的增大

药物释放速率减缓;药物在水及pH 6.8的磷酸盐缓冲液中释放行为相似

但在pH 1.0的盐酸溶液中释放速率降低;释放方法对药物释放速率无显著影响。结论:此片剂药物释放主要以渗透压梯度驱动机制为主

少量药物则直接扩散释药。

Abstract

Objective:To study on drug release mechanism of panax notoginsenosides microporous membrane osmotic pump tablets（PNSMPOP）.Method: With comparing drug release behavior of PNSMPOP in different osmotic pressure medium and investigating effects of different release methods on drug release velocity

to investigate release mechanism of this preparation.Result: Drug release velocity declined with difference of osmotic pressure between inside and outside of coating film increased;Drug release behavior was similar between in distilled water and pH 6.8 phosphate buffer

but release rate decreased in pH 1.0 hydrochloric acid solution;There was no significant influence on drug release by different drug release methods.Conclusion: This tablet released mainly in gradient-driven mechanism of osmotic pressure between inside and outside of membrane

a small amount of drug released by directly spread.

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