Performance Comparison of Different Cross-linked Povidone

RAO Xiao-yong 1; LIU Wei 1; ZENG Wen-xue 2; ZHANG Guo-song 1; WANG Yue-sheng1; LUO Xiao-jian1

doi:10.13422/j.cnki.syfjx.2012.08.032

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Performance Comparison of Different Cross-linked Povidone

更新时间：2024-09-23

- Performance Comparison of Different Cross-linked Povidone
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 8, Pages: 18-21(2012)
- 作者机构：
  
  1. 中药固体制剂制造技术国家工程研究中心
  2. 江西中医学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.08.032
  CLC： R283.6
- Published：2012
- 稿件说明：
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[1]饶小勇,刘微,曾文雪,张国松,王跃生,罗晓健.不同交联聚维酮性能比较及其在中药中的应用[J].中国实验方剂学杂志,2012,18(08):18-21.

RAO Xiao-yong 1, LIU Wei 1, ZENG Wen-xue 2, et al. Performance Comparison of Different Cross-linked Povidone[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 18-21.
[1]饶小勇,刘微,曾文雪,张国松,王跃生,罗晓健.不同交联聚维酮性能比较及其在中药中的应用[J].中国实验方剂学杂志,2012,18(08):18-21. DOI： 10.13422/j.cnki.syfjx.2012.08.032.

RAO Xiao-yong 1, LIU Wei 1, ZENG Wen-xue 2, et al. Performance Comparison of Different Cross-linked Povidone[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 18-21. DOI： 10.13422/j.cnki.syfjx.2012.08.032.

摘要

目的:研究不同交联聚维酮性质及其在中药中应用的差异性。方法:选取4种国产交联聚维酮和3种进口交联聚维酮

对其粒子形态、流动性、溶胀性、吸水速度常数、比表面积等进行研究;以穿心莲片、十全大补片、六味地黄片处方为模型

考察不同交联聚维酮崩解性能。结果:不同交联聚维酮在粉体学性质和功能性参数方面均存在一定的差异

尤其作为崩解剂应用于中药中

崩解性能进口交联聚维酮明显优于国产交联聚维酮。结论:国产交联聚维酮性能有待于优化。

Abstract

Objective:To study on difference of properties of cross-linked povidone（PVPP） and its application in the traditional Chinese medicine.Method: Four kinds of domestic PVPP and three kinds of imported PVPP were chosen

and to study on particle morphology

mobility

swelling capacity

water absorption rate constant and specific surface area

etc;Performance of different PVPP was investigated with Chuangxinlian tablet

Shiquan Dabu tablet

Liuwei Dihuang tablet as model medicine.Result: There were some differences in powder properties and functional parameters of different PVPP

especially it was used in model medicine as disintegrating agent

imported PVPP was better than domestic PVPP on disintegrating performance.Conclusion: Performance of domestic PVPP need to be optimized.

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