Simultaneous Determination Muscone,Borneol, Camphor and Isoborneol in Xingnaojing Injection by GC

FANG Ying1; ZHAO Xi-xian2; ZHAO Ming-shu2; GONG Wei-hong3; WANG Qing-gang2; MENG Da-jun2

doi:10.13422/j.cnki.syfjx.2012.08.045

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Simultaneous Determination Muscone,Borneol, Camphor and Isoborneol in Xingnaojing Injection by GC

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- Simultaneous Determination Muscone,Borneol, Camphor and Isoborneol in Xingnaojing Injection by GC
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 8, Pages: 96-99(2012)
- 作者机构：
  
  1. 北京市药品检验所
  2. 北京市东城区药品检验所
  3. 北京中医药大学中药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.08.045
  CLC： R286.0
- Published：2012
- 稿件说明：
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[1]方颖,赵希贤,赵鸣舒,龚卫红,王庆纲,孟大钧.气相色谱法同时测定醒脑静注射液中麝香酮、龙脑、樟脑、异龙脑的含量[J].中国实验方剂学杂志,2012,18(08):96-99.

FANG Ying1, ZHAO Xi-xian2, ZHAO Ming-shu2, et al. Simultaneous Determination Muscone,Borneol, Camphor and Isoborneol in Xingnaojing Injection by GC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 96-99.
[1]方颖,赵希贤,赵鸣舒,龚卫红,王庆纲,孟大钧.气相色谱法同时测定醒脑静注射液中麝香酮、龙脑、樟脑、异龙脑的含量[J].中国实验方剂学杂志,2012,18(08):96-99. DOI： 10.13422/j.cnki.syfjx.2012.08.045.

FANG Ying1, ZHAO Xi-xian2, ZHAO Ming-shu2, et al. Simultaneous Determination Muscone,Borneol, Camphor and Isoborneol in Xingnaojing Injection by GC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 96-99. DOI： 10.13422/j.cnki.syfjx.2012.08.045.

摘要

目的:建立毛细管气相色谱法同时测定醒脑静注射液中麝香酮、龙脑、樟脑、异龙脑的含量。方法:采用气相色谱法

DB-FFAP（0.1μm×0.53 mm×30 m）毛细管色谱柱分离测定

FID检测器。进样口温度230℃。检测器温度240℃。用氮气作为载气

流速2.5 mL·min-1;色谱柱采用梯度升温

开始温度85℃

以5℃·min-1的升温速率升至185℃

以20℃·min-1的升温速率升至215℃

以1℃·min-1的升温速率升至230℃

保持5 min。分流比15∶1

进样量1μL

外标法定量。结果:麝香酮、龙脑、樟脑、异龙脑在同一色谱条件下获得分离

麝香酮、龙脑、樟脑、异龙脑在测定范围内呈良好线性关系

回收率符合要求。结论:方法简便、灵敏、准确

分离度、重复性好。

Abstract

Objective:To establish the simultaneous determination of muscone

borneol

camphor and isoborneol in Xingnaojing Injection.Method: The GC system consisted of capillary column

DB-FFAP-30M;FID as the detector.The column temperature was programmed from 85 ℃ to 185 ℃ at 5 ℃·min-1

then to 215 ℃ at 20 ℃·min-1

to 230 ℃ at 1 ℃·min-1（holding 5 minutes）.The inlet temperature was 230 ℃.The detect temperature was 240 ℃.Nitrogen was used as carrying gas（2.5 mL·min-1）.The split ratio was 15∶1;injection volume was 1 μL.The external standard method was employed.Result: Muscone

borneol

camphor and isoborneol in Xingnaojing Injection have been separated well under the same chromatographic condition.Muscone

borneol

camphor and isoborneol are in the determination of a good linear relationship within the scope.Recovery rate of the determination method all corresponded to the experimental standard.Conclusion: The method is simple

sensitive

accurate

separable and reproducible

and can be used to control the quality of Xingnaojing Injection.

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Related Author

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WANG Qing-gang

MENG Da-jun

LIU Feng

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Related Institution

Institute of Frontier Medical Science of Jilin University

National Institute for Food and Drug Control

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Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine

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