Study on the Fingerprint of Chuanxiong Intermediate

CHEN Ji-you1; GUO Li-rong2; TONG Yu-lin2; LIU Chang-qing2

doi:10.13422/j.cnki.syfjx.2012.08.046

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Study on the Fingerprint of Chuanxiong Intermediate

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- Study on the Fingerprint of Chuanxiong Intermediate
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 8, Pages: 100-105(2012)
- 作者机构：
  
  1. 广州市中西医结合医院
  2. 广州中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.08.046
  CLC： R284.1
- Published：2012
- 稿件说明：
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[1]陈积优,郭丽蓉,童玉林,刘常青.川芎HPD-100大孔树脂和醇沉纯化物指纹图谱研究[J].中国实验方剂学杂志,2012,18(08):100-105.

CHEN Ji-you1, GUO Li-rong2, TONG Yu-lin2, et al. Study on the Fingerprint of Chuanxiong Intermediate[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 100-105.
[1]陈积优,郭丽蓉,童玉林,刘常青.川芎HPD-100大孔树脂和醇沉纯化物指纹图谱研究[J].中国实验方剂学杂志,2012,18(08):100-105. DOI： 10.13422/j.cnki.syfjx.2012.08.046.

CHEN Ji-you1, GUO Li-rong2, TONG Yu-lin2, et al. Study on the Fingerprint of Chuanxiong Intermediate[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 100-105. DOI： 10.13422/j.cnki.syfjx.2012.08.046.

摘要

目的:建立川芎HPD-100大孔树脂纯化物及醇沉纯化物的指纹图谱

筛选较优纯化方法并为有效控制其质量提供可靠方法。方法:高效液相色谱法

Phenomenex Hyperclone BDS C18（4.00 mm×250 mm

5μm）

甲醇-1%冰乙酸为流动相

梯度洗脱（0～35 min

20∶80～45∶55

35～55 min

45∶55～70∶30

55～70 min

70∶30～80∶20）

322 nm检测。结果:川芎HPD-100大孔树脂纯化物共有22个共有峰

川芎醇沉纯化物共有20个共有峰

分离好

相似度均在0.98以上

重复性好。结论:川芎采用HPD-100大孔树脂纯化较好。本方法科学、准确、专属性好

可为川芎药材及含川芎的中成药质量控制提供可靠的科学依据。

Abstract

Objective:To establish the HPLC fingerprint of Chuanxiong Intermediate and provide a method to control the quality of Chuanxiong.Method:HPLC method was applied for quality assessment of Chuanxiong Intermediate.HPLC analysis was performed on a Phenomenex Hyperclone BDS C18（4.00 mm×250 mm

5 μm） by gradient elution using methanol-1% acetic acid solution as mobile phase.Flow-rate was 1 mL·min-1.The detection wavelength was at 322 nm.Result: The intermediate of Rhizoma Chuanxiong were closely related to each other.Conclusion: The method is rapid and accurate.It was used for determination of Chuanxiong Intermediate and Chinese formulated medicine with it.

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Related Author

CHEN Ji-you

GUO Li-rong

TONG Yu-lin

LIU Chang-qing

LI Li

ZHANG Cun

XIAO Yong-qing

Lin Na

Related Institution

Guangdong Province Institute of Traditional Chinese Medicine

Jiangxi University of Chinese Medicine

Nanchang Medical College

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

School of Pharmacy， Jiangxi University of Chinese Medicine

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