CHEN Yong-shun, WU Zhen. In vivo Pharmacokinetics and Tissue Distribution of Wogonin Albumin Microspheres in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 137-140.
CHEN Yong-shun, WU Zhen. In vivo Pharmacokinetics and Tissue Distribution of Wogonin Albumin Microspheres in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 137-140. DOI: 10.13422/j.cnki.syfjx.2012.08.055.
In vivo Pharmacokinetics and Tissue Distribution of Wogonin Albumin Microspheres in Rats
Objective:To study on in vivo pharmacokinetics and tissue distribution of wogonin albumin microspheres in rats.Method: The concentration of wogonin in plasma of rats was determined by HPLC and pharmacokinetics parameters after tail intravenous administration were calculated by software program 3P97 with wogonin solution as reference.Targeting efficiency(Te) was used to evaluate in vivo tissue distribution and targeting of wogonin albumin microspheres in rats.Result: Pharmacokinetic model of wogonin albumin microspheres in rats was in line with a two-compartment model
and main pharmacokinetic parameters were as follows: t1/2α=(0.550 0±0.128 2) h
t1/2β=(14.776 1±1.578 2) h
CL=(0.005 96±0.001 4) mL·h·kg-1
AUC0→∞=(126.3317±9.5012) mg·h·L-1.Compared with wogonin solution
Te in live
spleen
heart
hung and kidney were 2.21
2.02
0.581
0.64
0.26
respectively.Conclusion: Compared with wogonin solution
wogonin albumin microspheres could improve tendency in liver and spleen
and it could enhance therapeutic effect of wogonin albumin microspheres in rats.
Effect of Borneol on Pharmacodynamics,Pharmacokinetics and Brain Tissue Distribution of Main Active Ingredients of Jiaotaiwan in Depression Model Rats
Pharmacokinetics and Tissue Distribution of Silybin Gelatin Microspheres in Rats
Preparation and its Release of Wogonin Albumin Microspheres
Related Author
CHEN Yong-shun
WU Zhen
YU Meishuang
DAI Guoliang
HANG Huaxi
YE Yu
WANG Yiran
SHAO Xuewen
Related Institution
Affiliated Hospital of Nanjing University of Chinese Medicine
School of Life Sciences,Beijing University of Chinese Medicine
Third Grade Laboratory of Traditional Chinese Medicine(TCM) Preparations,National Administration of TCM,Shuguang Hospital Affiliated to Shanghai University of TCM
School of Pharmacy, Hunan University of Chinese Medicine
Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China,Southwest Minzu University