Effect of Compatibility on Intestinal Absorption of Alkaloids in Fructus Evodiae and Rhizoma Coptidis in Rats

ZOU Li-juan1; CHEN Ying2; YANG Qing2; LI Yu-jie2; WANG Yi-wei2; WENG Xiao-gang2; DONG Yu3; MEN Wei1; ZHU Xiao-xin1

doi:10.13422/j.cnki.syfjx.2012.08.057

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Effect of Compatibility on Intestinal Absorption of Alkaloids in Fructus Evodiae and Rhizoma Coptidis in Rats

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- Effect of Compatibility on Intestinal Absorption of Alkaloids in Fructus Evodiae and Rhizoma Coptidis in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 8, Pages: 147-151(2012)
- 作者机构：
  
  1. 首都医科大学中医药学院
  2. 中国中医科学院中药研究所
  3. 中国中医科学院广安门医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.08.057
  CLC： R285;R284.1
- Published：2012
- 稿件说明：
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[1]邹丽娟,陈颖,杨庆,李玉洁,王怡薇,翁小刚,董宇,门薇,朱晓新.吴茱萸对黄连生物碱在大鼠肠道吸收中的影响研究[J].中国实验方剂学杂志,2012,18(08):147-151.

ZOU Li-juan1, CHEN Ying2, YANG Qing2, et al. Effect of Compatibility on Intestinal Absorption of Alkaloids in Fructus Evodiae and Rhizoma Coptidis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 147-151.
[1]邹丽娟,陈颖,杨庆,李玉洁,王怡薇,翁小刚,董宇,门薇,朱晓新.吴茱萸对黄连生物碱在大鼠肠道吸收中的影响研究[J].中国实验方剂学杂志,2012,18(08):147-151. DOI： 10.13422/j.cnki.syfjx.2012.08.057.

ZOU Li-juan1, CHEN Ying2, YANG Qing2, et al. Effect of Compatibility on Intestinal Absorption of Alkaloids in Fructus Evodiae and Rhizoma Coptidis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 147-151. DOI： 10.13422/j.cnki.syfjx.2012.08.057.

摘要

目的:研究吴茱萸对黄连中小檗碱和巴马汀在大鼠肠道吸收中的影响及其机制。方法:采用大鼠单向肠灌流模型

考察维拉帕米和吴茱萸提取物对小檗碱和巴马汀在各肠段吸收的影响

利用HPLC分别测定小檗碱和巴马汀的量

计算两种生物碱的肠吸收速率常数（Ka）和表观吸收系数（Papp）。结果:黄连提取物和吴茱萸提取物配比为6∶12时小檗碱和巴马汀的Ka和Papp显著增加。黄连生物碱单体化合物小檗碱、巴马汀与吴茱萸提取物6∶12配伍时

能明显促进小檗碱和巴马汀的吸收;6∶1配伍时

减弱小檗碱的吸收

促进巴马汀的吸收。P-糖蛋白（P-gp）抑制剂维拉帕米的存在均能促进小檗碱和巴马汀的吸收。结论:黄连配伍吴茱萸可促进黄连中小檗碱和巴马汀的肠吸收

其机制可能与抑制P-gp的活性有关。

Abstract

Objective:To study the effect of compatibility with Fructus Evodiae on intestinal absorption of alkaloids in Rhizoma Coptidis and its mechanism in rats.Method: In situ single-pass perfused rat intestinal model was used and the concentrations of berberine and palmatine were determined by HPLC.The drug absorption rate constant（Ka） and apparent absorption coefficient（Papp） were tested to evaluate the effect of compatibility with verapamil or Fructus Evodiae on their absorption.Result: Rhizoma Coptidis extractive and Fructus Evodiae extractive（6∶12） can significantly enhance Ka and Papp of berberine and palmatine.Two alkaloids in Rhizoma Coptidis and Fructus Evodiae extractive（6∶12） promoted their intestine absorption.When the compatible proportion was 6∶1

the absorption of berberine decreased

and the absorption of palmatine increased.Verapamil had a promoting effect on the absorption of berberine and palmatine.Conclusion: Fructus Evodiae extractive can promote the intestine absorption of berberine and palmatine

and the mechanism may be related to its inhibition of P-glycoprotein activity.

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Related Author

ZOU Li-juan

CHEN Ying

Yang Qing

LI Yu-jie

WANG Yi-wei

WENG Xiao-gang

DONG Yu

MEN Wei

Related Institution

Institute of Chinese Materia Medica,China Academy of Chinese Medical Science

The Guangzhou University of Traditional Chinese Medicine

Guang’anmen Hospital,China Academy of Chinese Medical Science

College of Pharmacy,Chengdu University of Traditional Chinese Medicine

江西科技师范大学药学院

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