Objective:To study the anti-inflammatory effect and mechanism of Aralia echinocaulis Hand-Mazzin produced in Guizhou.Method: Dimethylbenzene and carrageenin were used to

respectively

to cause ears edema in mice and paw swelling in rats;medical cotton and freund’s complete adjuvant were used to

respectively

reduce granulomatous inflammation in mice and adjuvant arthritis（AA）in rats.Rats were randomly divided into control group

model group

positive drug group（tripterygium wilfordii 12 mg·kg-1）

A.echinocaulis high dosage group

middle dosage group

low dosage group（the dosage 3.5

1.75

0.88 g·kg-1）.The corresponding drugs were given at the day of modelling for 35 days.Nitric oxide（NO） content in serum was detected by nitrate reductase method and the level of interleukin-1β（IL-1β）

tumor necrosis factor-α（TNF-α） was measured with radioimmunoassay（RIA）.Result: High dosage group and middle dosage group of A.echinocaul were inhibited the ear edema in mice and swelling of paw（P<0.01

P<0.05）;meanwhile granuloma inflammation in mice was reduced（P<0.05）

the level of NO

IL-1β and TNF-α was decreased（P<0.01

P<0.05）.Conclusion:A.echinocaul can restrain inflammatory reaction

the mechanism of which may be related to inhibiting secretion of NO

L-1β and TNF-α