Objective:To investigate the effect of hypoxia inducible factor-1α（HIF-1α） and vascular endothelial growth factor（VEGF） in airway remodeling of chronic asthmatic rats

to reseach the mechanism of Shegan Mahuang Tang in asthma treatment.Method:Forty SD rats were randomly divided into four groups:the asthma chronic model group（group A）

the Shegan Mahuang Tang low dose group（group B）

the Shegan Mahuang Tang high dose group（group C） and the control group（group D）.The asthmatic rat model was established by sensitization and challenge with ovalbumin（OVA）.And the rats in B

C group were administrated the Shegan Mahuang Tang by ig（0.96

3.84 g·kg-1

respectively）

and in A

D group administrated the equal physiological saline in the same way for eight weeks.The airway total wall thickness（Wat/Pbm）

the airway inwall thickness（Wai/Pbm）

the bronchial smooth muscle thickness（WAm/Pi） were measured by using image analysis system.Immunohistochemistry and RT-PCR were used to measure the level of HIF-1α and VEGF protein and mRNA in the rats′lung tissues.Result:Wat/Pbm

Wai/Pbm

Wam/Pbm in group A [（68.19±4.48）

（38.27±1.62）

（7.61±1.33）μm2/μm

respectively] were all significantly higher than those in group D [（34.76±1.38）

（16.25±2.20）

（2.89±0.45）μm2/μm

respectively

P<0.05].The expression of HIF-1α and VEGF protein and mRNA in the lung tissues of the asthmai model group was higher than that in the other groups（P<0.05）.After Shegan Mahuang Tang therapy

the thickness of the airway wall

the HIF-1α and VEGF levels in Shegan Mahuang Tang group were decreased compared to the asthma model group（P<0.05）.HIF-1α and VEGF protein and mRNA expressions were positively correlated with airway wall thickness.Conclusion: Shegan Mahuang Tang may decline the expression of HIF-1α

VEGF protein and mRNA and inhibition airway remodeling in asthmatic chronic rats.And its effect was positively correlated with its dosage.