The Effect of Shiteng Capsules on TNF-α and IL-1β in Rats with Adjuvant Arthritis

WANG Zhen-liang 1 YAO Nai-li2

doi:10.13422/j.cnki.syfjx.2012.08.069

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The Effect of Shiteng Capsules on TNF-α and IL-1β in Rats with Adjuvant Arthritis

更新时间：2024-09-23

- The Effect of Shiteng Capsules on TNF-α and IL-1β in Rats with Adjuvant Arthritis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 8, Pages: 195-198(2012)
- 作者机构：
  
  1. 河南中医学院仲景医药研究所
  2. 中国中医科学院广安门医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.08.069
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]王振亮,姚乃礼.石藤胶囊对佐剂性关节炎大鼠TNF-α,IL-1β的影响[J].中国实验方剂学杂志,2012,18(08):195-198.

WANG Zhen-liang 1 YAO Nai-li2. The Effect of Shiteng Capsules on TNF-α and IL-1β in Rats with Adjuvant Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 195-198.
[1]王振亮,姚乃礼.石藤胶囊对佐剂性关节炎大鼠TNF-α,IL-1β的影响[J].中国实验方剂学杂志,2012,18(08):195-198. DOI： 10.13422/j.cnki.syfjx.2012.08.069.

WANG Zhen-liang 1 YAO Nai-li2. The Effect of Shiteng Capsules on TNF-α and IL-1β in Rats with Adjuvant Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 195-198. DOI： 10.13422/j.cnki.syfjx.2012.08.069.

摘要

目的:观察石藤胶囊对大鼠佐剂性关节炎（adjuvant arthritis

AA）血清肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）含量的影响。方法:采用弗氏完全佐剂诱导的大鼠AA模型。选用Wistar大鼠

造模后第19天

将出现多发性关节炎症状的大鼠随机选取24只

并随机分为模型组、石藤胶囊组、雷公藤组

每组8只。注射生理盐水大鼠8只作为正常对照组。各组按每日10 mL·kg-1连续灌胃给药或给等体积生理盐水

持续21 d。其中石藤胶囊组每日灌服石藤胶囊0.75 g.kg-1

雷公藤组每日灌服雷公藤多苷片6 mg·kg-1

模型组和正常组灌服等体积的生理盐水。放射免疫法测定大鼠血清TNF-α

IL-1β

同时观察大鼠足爪肿胀抑制率、关节炎指数及关节病理积分的变化。结果:石藤胶囊可以明显降低AA大鼠血清TNF-α[模型组为（1.25±0.22）μg·L-1

石藤胶囊组为（0.88±0.11）μg·L-1

两组对比P<0.01]和IL-1β水平[模型组为（0.28±0.05）μg·L-1

石藤胶囊组为（0.20±0.03）μg·L-1

两组对比P<0.01)]

降低AA大鼠的足爪肿胀度

提高对关节肿胀的抑制率。结论:石藤胶囊能够通过降低血清TNF-α和IL-1β水平对AA发挥治疗作用。

Abstract

Objective:To observe the effect of Shiteng capsules on the content of tumor necrosis factor-α（TNF-α）and interleukin-1β（IL-1β）in blood serum of rats with adjuvant arthritis（AA）.Method: Thirty-two Wistar rats were randomly divided into 4 groups as follows: control group

model group

shiteng capsules group

tripterygium wilfordii group.The model was induced by Freund’s complete adjuvant.The TNF-α and IL-1β level in blood serum was detected by radioimmunity

at the same time

the inhibition ratio of paw edema

arthritis index and pathological score was observed.Result: Shiteng capsules cauld decrease TNF-α and IL-1β level in rats with AA obviously（compared with model group

P<0.01）

and increse the inhibition ratio of paw edema.Conclusion: Shiteng capsules can play therapeutical effect to AA by redusing the levevl of serum TNF-α and IL-1β.

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Related Institution

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