Objective:To observe the antitumor effects of extract from Christia vespertilionis in vivo.Method: The mice S180-mice model and H22-mice model were established by inoculation into subaxillary with 0.2 mL tumor cell suspension.After 24 h of inoculation

mice were randomly divided into five groups

extract from C.vespertilionis low-dose

middle-dose and high-dose group

tumor-bearing control group

positive control group.The extract from C.vespertilionis at dose of 3

6

12 g·kg-1

was ig administrated

for 10 days.The tumor-inhibition rate of extract from C.vespertilionis were tested with S180-mice model and H22-mice model in vivo

the immune function and hematopoietic system of tumor-bearing mice were observed

and the S180-mice model and H22-mice model was used to test the survival rate.Result:Compare to the tumor-bearing control group

the extract from C.vespertilionis could significantly inhibit the growth of S180 tumor and H22 tumor cells（P<0.01 or P<0.05）

and the inhibition rate at high-dose group nwas 54.42%

60.77%

respectively.The extract could also greatly prolong life of the mice with S180 and H22 ascitic tumor

and life span at high-dose was 82.13%

83.10%

respectively.No significant changes in immune function and hematopoietic system of tumor-bearing mice were found.Conclusion: The extract from C.vespertilionis is able to significantly inhibit tumor growth and prolong the survival period of the tumor-bearing mice.