Effect of Jianpi Oral Liquid on Gastrointestinal Motilityand Gastrointestinal Hormones in Mice Withsyndrome of Spleen-deficiency

LI Feng-jin; ZHANG Yu-kun; LIU Hong-tao; LIU Jin-quan; NIU Wen-ying; XIAO Hong-bin

doi:10.13422/j.cnki.syfjx.2012.08.074

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Effect of Jianpi Oral Liquid on Gastrointestinal Motilityand Gastrointestinal Hormones in Mice Withsyndrome of Spleen-deficiency

更新时间：2024-09-23

- Effect of Jianpi Oral Liquid on Gastrointestinal Motilityand Gastrointestinal Hormones in Mice Withsyndrome of Spleen-deficiency
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 8, Pages: 212-215(2012)
- 作者机构：
  
  黑龙江中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.08.074
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]李凤金,张玉昆,刘泓涛,刘锦泉,牛雯颖,肖洪彬.健脾口服液对脾虚证小鼠胃肠运动功能及胃肠激素分泌的影响[J].中国实验方剂学杂志,2012,18(08):212-215.

LI Feng-jin, ZHANG Yu-kun, LIU Hong-tao, et al. Effect of Jianpi Oral Liquid on Gastrointestinal Motilityand Gastrointestinal Hormones in Mice Withsyndrome of Spleen-deficiency[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 212-215.
[1]李凤金,张玉昆,刘泓涛,刘锦泉,牛雯颖,肖洪彬.健脾口服液对脾虚证小鼠胃肠运动功能及胃肠激素分泌的影响[J].中国实验方剂学杂志,2012,18(08):212-215. DOI： 10.13422/j.cnki.syfjx.2012.08.074.

LI Feng-jin, ZHANG Yu-kun, LIU Hong-tao, et al. Effect of Jianpi Oral Liquid on Gastrointestinal Motilityand Gastrointestinal Hormones in Mice Withsyndrome of Spleen-deficiency[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 212-215. DOI： 10.13422/j.cnki.syfjx.2012.08.074.

摘要

目的:研究健脾口服液对脾虚小鼠胃肠运动功能及胃肠激素分泌的影响

探讨健脾口服液调节胃肠运动功能的机制。方法:60只昆明种小鼠

随机分为6组即健脾口服液高、中、低剂量组、阳性药对照组、模型对照组、正常对照组

每组10只;健脾口服液高、中、低剂量组给药量分别为22.88

11.44

5.72 g·kg-1;启脾口服液为8 mL·kg-1;正常组及模型组给以等体积生理盐水

每天ig给药1次

造模14 d后开始用药

持续给药7d。观察健脾口服液对脾虚小鼠胃肠运动功能及胃泌素、血管活性肽含量的影响。结果:健脾口服液各剂量组均可不同程度的提高脾虚模型小鼠胃甲基橙残留率

降低脾虚模型小鼠小肠内容物推进率

差异有显著性意义;健脾口服液各剂量组均可不同程度的提高脾虚模型小鼠血浆中胃泌素（GAS）、降低血管活性肽（VIP）含量

差异有显著性意义。结论:健脾口服液可以改善脾虚泄泻小鼠胃排空功能和小肠推进功能

提高胃泌素和降低血管活性肽含量可能是治疗脾虚证的作用机制之一。

Abstract

Objective:To study the effect of Jianpi oral liquid（JPOL）on gastrointestinal motility

gastrointestinal hormones in mice with syndrome of spleen-deficiency to explore the mechanism.Method: Sixty mice were randomly divided into six groups: normal group

model group

low dose JPOL group

middle dose JPOL group

high dose JPOL group and positive control group（10 each group

including half male and half female）.The normal group and model group were given physiological saline of 15 mL·kg-1;while JPOL groups were administrated with JPOL at dose of 22.88

11.44

5.72 g·kg-1 respectively

and positive control group was given Qipi oral liquid（QPOL） of 8 mL·kg-1.Observation started from 14 days after modelling and administration of 7 successive days.Gastrointestinal motility

gastrins（GAS） and vasoactive intestinal peptide（VIP） in each group were observed.Result: Different doses of JPOL could improve the function of gastric emptying and inhabit small bowel peristalsis of mices to different extent.The different doses of JPOL could increase the content of GAS and decrease the content of VIP to different extent.Conclusion: The effect of JPOL may result from improving the function of gastric emptying

inhabiting small bowel peristalsis

the mechanism of which may be related to increasing the level of GAS and decreasing the level of VIP.

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Related Author

LI Feng-jin

ZHANG Yu-kun

LIU Hong-tao

LIU Jin-quan

NIU Wen-ying

XIAO Hong-bin

BAI Yaya

TIAN Rui

Related Institution

Hanlin College，Nanjing University of Chinese Medicine

Shaanxi Engineering Technology Research Center of Chinese Herbal Pieces，Shaanxi Qinling Application Development and Engineering Research Center of Chinese Herbal Medicine，Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine（TCM） for TCM Compatibility， Shaanxi University of Chinese Medicine，Xi′an

Graduate School， Changchun University of Chinese Medicine

Graduate School，Beijing University of Chinese Medicine

Institute of Metabolic Diseases，Guang'anmen Hospital，China Academy of Chinese Medical Sciences

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