Experimental Study on IL-11 and EPO in Aplastic Anemia Rat Treated with Tonifying Kidney and Replenishing Essence Prescription.

QIN Lan1; CHEN Xin-yi2; SHAN Li-juan3; XIE Rong3

doi:10.13422/j.cnki.syfjx.2012.08.077

您当前的位置：

首页 >

文章列表页 >

Experimental Study on IL-11 and EPO in Aplastic Anemia Rat Treated with Tonifying Kidney and Replenishing Essence Prescription.

更新时间：2024-09-23

- Experimental Study on IL-11 and EPO in Aplastic Anemia Rat Treated with Tonifying Kidney and Replenishing Essence Prescription.
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 8, Pages: 225-227(2012)
- 作者机构：
  
  1. 新疆医科大学附属中医院血液科
  2. 北京东直门医院血液科
  3. 新疆医科大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.08.077
  CLC： R285.5
- Published：2012
- 稿件说明：
移动端阅览
[1]秦兰,陈信义,单丽娟,谢荣.补肾填精方对再生障碍性贫血大鼠模型IL-11及EPO影响的研究[J].中国实验方剂学杂志,2012,18(08):225-227.

QIN Lan1, CHEN Xin-yi2, SHAN Li-juan3, et al. Experimental Study on IL-11 and EPO in Aplastic Anemia Rat Treated with Tonifying Kidney and Replenishing Essence Prescription.[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 225-227.
[1]秦兰,陈信义,单丽娟,谢荣.补肾填精方对再生障碍性贫血大鼠模型IL-11及EPO影响的研究[J].中国实验方剂学杂志,2012,18(08):225-227. DOI： 10.13422/j.cnki.syfjx.2012.08.077.

QIN Lan1, CHEN Xin-yi2, SHAN Li-juan3, et al. Experimental Study on IL-11 and EPO in Aplastic Anemia Rat Treated with Tonifying Kidney and Replenishing Essence Prescription.[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 225-227. DOI： 10.13422/j.cnki.syfjx.2012.08.077.

摘要

目的:观察补肾填精方对再生障碍性贫血（aplastic anemia

AA）模型大鼠调控因子白细胞介素-11（interleukin-11

IL-11）及红细胞生成素（erythropoietin

EPO）的影响。方法:Wistar大鼠随机分为空白对照组、模型生理盐水组、补肾填精中药组、再障生血片组共4组各12只

对照组正常饲喂不做干预;其他3组以5-氟尿嘧啶注射液（5-FU）与马利兰合用诱发建立模型后

补肾填精中药组及再障生血片组分别给予补肾填精中药10 g·kg-1及再障生血片混悬液0.015 g·kg-1

连续4周

模型组予等量生理盐水灌胃。结果:①治疗组的白细胞（WBC）、血红蛋白（Hb）、红细胞（RBC）及血小板（PLT）较模型组均有不同程度增高

差异有统计学意义（P<0.05）。其中补肾填精中药组的WBC和PLT明显升高

差异有统计学意义（P<0.01）。②治疗组IL-11含量较模型组升高

差异有统计学意义（P<0.05）。③治疗组EPO含量较模型组降低

差异有统计学意义（P<0.05）。结论:补肾填精方能改善模型大鼠的骨髓造血功能

可改善细胞因子IL-11及EPO介导的分泌异常

促进骨髓造血功能的恢复。

Abstract

Objective:To observed the effect of tonifying kidney and replenishing essence prescription（TKREP） on two regulation factors interleukin-11（IL-11） and eryhropictin（EPO） in Aplastic Anemia（AA） rats.Method: Forty eight clean grade Wistar rats were randomly divided into 4 groups

namely normal control group

AA model group

TKREP group and the aplastic blood-forming tablet（ABFT）group.The normal control group was fed with normal foods and vihicle.The other three groups were given the fluorouracil（5-FU） plus Myleran to induce AA model of rat.After that

the TKREP group and ABFT group rats were fed with TKREP（10 g·kg-1·d-1）and ABFT（0.015 g·kg-1·d-1） for 4 weeks.While

the AA model group was fed 0.9% NaCl.Result:①Compared to model group

the numbers of red blood cells and hemoglobin in treatment group were decreased

the difference was statistically significant（P<0.05）;the numbers of white blood cells and platelet in TKREP group were significantly decreased

the difference was statistically significant（P<0.01）;②EPO levels were elevated in treatment group

the difference was statistically significant（P<0.05）;③while the IL-11 level was increased slightly

the difference was statistically significant（P<0.05）.Conclusion: From point view of tonifying kidney

the TKREP could significantly improve bone marrow hematopoietic function against 5-FU plus Myleran

to a certain extent

effectively improve abnormal secreteing of regulation factors（IL-11 and EPO） and encouraged the bone marrow hematopoietic function’s recover.

关键词

Keywords

references

Views

143

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

QIN Lan

CHEN Xin-yi

SHAN Li-juan

XIE Rong

Related Institution

No data

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰