Uniform Designed Research on the Active Ingredients Assembling of Chinese Herbal for Reducing the Carcinogen of PAHs

YANG Hong1; WU Yan2; MA Yan-yan1; LI Jing-zhe1; LV Jun-hai1

doi:10.13422/j.cnki.syfjx.2012.08.078

您当前的位置：

首页 >

文章列表页 >

Uniform Designed Research on the Active Ingredients Assembling of Chinese Herbal for Reducing the Carcinogen of PAHs

更新时间：2024-09-23

- Uniform Designed Research on the Active Ingredients Assembling of Chinese Herbal for Reducing the Carcinogen of PAHs
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 8, Pages: 228-231(2012)
- 作者机构：
  
  1. 中国中医科学院医学实验中心
  2. 广西中烟工业有限责任公司技术中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.08.078
  CLC： R285.5
- Published：2012
- 稿件说明：
移动端阅览
[1]杨鸿,吴彦,马琰岩,李晶哲,吕俊海.清除致癌物多环芳烃的中药组分复方配伍研究[J].中国实验方剂学杂志,2012,18(08):228-231.

YANG Hong1, WU Yan2, MA Yan-yan1, et al. Uniform Designed Research on the Active Ingredients Assembling of Chinese Herbal for Reducing the Carcinogen of PAHs[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 228-231.
[1]杨鸿,吴彦,马琰岩,李晶哲,吕俊海.清除致癌物多环芳烃的中药组分复方配伍研究[J].中国实验方剂学杂志,2012,18(08):228-231. DOI： 10.13422/j.cnki.syfjx.2012.08.078.

YANG Hong1, WU Yan2, MA Yan-yan1, et al. Uniform Designed Research on the Active Ingredients Assembling of Chinese Herbal for Reducing the Carcinogen of PAHs[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 228-231. DOI： 10.13422/j.cnki.syfjx.2012.08.078.

摘要

目的:基于均匀设计方法研究多种中药有效组分体外清除致癌物多环芳烃的最佳配伍作用。方法:采用改进最小角（least angle regression

LARS）回归分析

通过荧光光谱法进行甘草总黄酮、银杏叶提取物、淫羊藿总黄酮和黄芪总苷4个中药组分不同配比清除多环芳烃的作用研究。结果:通过LRAS回归分析获得了中药组分配伍清除多环芳烃的回归方程

优化组合后进行药效学验证

结果显示该中药组分配伍最佳剂量组合为甘草总黄酮3.144 g·L-1、银杏叶提取物0.8 g·L-1、淫羊藿总黄酮0.024 g·L-1和黄芪总苷0.036 g·L-1。结论:上述中药组分配伍后能有效清除致癌有害物质多环芳烃;本实验采用的均匀设计结合荧光光谱检测方法

为筛选评价中药组分配伍清除致癌物多环芳烃的作用提供了合适的研究方法。

Abstract

Objective:To find a suitable way of quantitative composition-activity relationship of Chinese herbal for reducing the carcinogen of polycyclic aromatic hydrocarbons（PAHs） based on uniform design.Method: Chinese herbal active ingredient formula was composed of total flavonoids of glycyrrhiza（TFG）

ginkgo biloba extract（GBE）

total flavonoids of epimedium（TFE） and astragaloside（AST）.The herbal efficacy was detected by scavenging polycyclic aromatic hydrocarbons in vivo.And the mathematical model was constructed to describe the connection between different combinations and their scavenging capacity by the method of least angle regression（LARS） regression.Result: The best effect was in the ratio of TFG 3.144 g·L-1

GBE 0.8 g·L-1

TFE 0.024 g·L-1

AST 0.036 g·L-1.Conclusion: Uniform designed research is one of efficient ways to describe the quantitative composition-activity relationship for reducing the carcinogen of PAHs.

关键词

Keywords

references

Views

223

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research of Active Ingredients of Chinese Herbal on Cavenging Polycyclic Aromatic Hydrocarbons and Radicals

Effect of Compatibility of Effective Monomer Components of Fujin Shengjisan on Angiogenesis of HUVEC Based on Uniform Design

Optimization and Mechanism Exploration of Tusizi Prescription for Ovarian Reserve Function Based on Uniform Design Method

Effect of Dose Compatibility of Main Chemical Components from Astragali Radix- Angelicae Sinensis Radix on Proliferation of VSMCs Based on Uniform Design

Related Author

YANG Hong

WU Yan

MA Yan-yan

LI Jing-zhe

LV Jun-hai

WU Yan

YANG Hong

HUANG Tai-song

Related Institution

School of Nursing， Chengdu University of Traditional Chinese Medicine

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Institute of Chinese Materia Medica， Shanghai University of Traditional Chinese Medicine

School of Mathematics，Southwest Jiaotong University

College of Integrated Traditional Chinese and Western Medicine，Medical School， Hunan University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰