Changes of Serum TNF-α,IL-1β,IL-4 in Rabbit with Acute Pulmonary Thromboembolism

YAO Yan-min; XU Tong-tong; WU Qi; LV Xiang-wei

doi:10.13422/j.cnki.syfjx.2012.08.088

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Changes of Serum TNF-α,IL-1β,IL-4 in Rabbit with Acute Pulmonary Thromboembolism

更新时间：2024-09-23

- Changes of Serum TNF-α,IL-1β,IL-4 in Rabbit with Acute Pulmonary Thromboembolism
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 8, Pages: 222-224(2012)
- 作者机构：
  
  广西省桂林市桂林医学院附属医院特需病区
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.08.088
  CLC： R563.5
- Published：2012
- 稿件说明：
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[1]姚艳敏,徐彤彤,武琦,吕祥威.兔急性肺血栓栓塞症血清TNF-α,IL-1β和IL-4的变化[J].中国实验方剂学杂志,2012,18(08):222-224.

YAO Yan-min, XU Tong-tong, WU Qi, et al. Changes of Serum TNF-α,IL-1β,IL-4 in Rabbit with Acute Pulmonary Thromboembolism[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 222-224.
[1]姚艳敏,徐彤彤,武琦,吕祥威.兔急性肺血栓栓塞症血清TNF-α,IL-1β和IL-4的变化[J].中国实验方剂学杂志,2012,18(08):222-224. DOI： 10.13422/j.cnki.syfjx.2012.08.088.

YAO Yan-min, XU Tong-tong, WU Qi, et al. Changes of Serum TNF-α,IL-1β,IL-4 in Rabbit with Acute Pulmonary Thromboembolism[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 222-224. DOI： 10.13422/j.cnki.syfjx.2012.08.088.

摘要

目的:监测兔急性肺血栓栓塞症（APTE）模型血清肿瘤坏死因子-α（TNF-α）

（白细胞介素-4

1β）IL-4

IL-1β水平的变化

探讨炎症因子与肺损伤的关系。方法:自体血栓法建立兔APTE模型

随机分为对照组、模型组。ELISA法检测血清各指标

术毕行病理分析。结果:栓塞后IL-4在发病早期未见升高

发病后6 h明显升高

模型组与对照组分别为（42.8±1.35）

（16.9±1.59）ng·mL-1（P<0.05）

栓塞后4 hTNF-α模型组与对照组分别为（3.52±0.42）

（1.29±0.36）ng·mL-1（P<0.05）

栓塞后2 h IL-1β模型组与对照组分别为（2.66±0.12）

（0.34±0.15）ng·mL-1（P<0.05）

水平明显高于对照组。形态学观察结果可见

栓塞后肺动脉内血栓形成

肺组织萎缩、出血、炎性反应明显。结论:APTE模型血清炎症因子发生的不同变化

在引起急性肺损伤中起重要作用。

Abstract

Objective:To monitor changes in serum TNF-α

interleukin-4（IL-4） and interlukin-1β（IL-1β） in rabbit with acute pulmonary thromboembolism（APTE）

and to investigate the relation between inflammatory factors and lung injury.Method: Rabbit APTE model was established by auto-thrombus.The rabbits were randomly divided into control group and model group.ELISA was employed to determine serum TNF-α

IL-4 and IL-1β.Pathological analysis was carried out after the experimental operation.Result: In the early stage of APTE

there was no significant change in the parameters.After 6 h of thromboembolism

IL-4 was（42.8±1.35） ng·mL-1

whereas（16.9±1.59） ng·mL-1 in the controls（P<0.05）.After 4 h and 2 h of thromboembolism

TNF-α and IL-1β were（3.52±0.42） ng·mL-1 and（2.66±0.12） ng·mL-1accordingly

whereas（1.29±0.36） ng·mL-1（P<0.05） and（0.34±0.15） ng·mL-1（P<0.05） in the controls.Pathological evidence showed that arterial thrombus

lung tissue atrophy

bleeding and inflammatory responses were significant.Conclusion: The inflammatory factors induced by APTE play important role in acute pulmonary lung injury.

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LV Xiang-wei

LI Yan-li

HU Yan-wu

YANG Ping

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Related Institution

Henan University of Traditional Chinses Medicine

Shandong Provincical Hospital of Traditional Chinese Medicine

Pharmacy College,Shandong University of Traditional Chinese Medicine

Basic Medical Sciences College,Shandong University of Traditional Chinese Medicine

College of Pharmacy and Chemistry,Dali University,Dali

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