ZHANG Xiao-mei, WANG Yun-hong, YANG Rong-ping, et al. Design,Optimization and Quality Evaluation of Artemisinin Self-emulsifying Preparation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 59-63.
ZHANG Xiao-mei, WANG Yun-hong, YANG Rong-ping, et al. Design,Optimization and Quality Evaluation of Artemisinin Self-emulsifying Preparation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 59-63. DOI: 10.13422/j.cnki.syfjx.2012.09.009.
Design,Optimization and Quality Evaluation of Artemisinin Self-emulsifying Preparation
Objective:To design and optimize technology of artemisinin self-emulsifying preparation
and evaluate its in vitro quality evaluation.Method:Excipients was selected by determining solubility of artemidinin in different oils
surfactants and co-surfactants.Based on ternary phase diagram
artemisinin self-emulsifying prescription was optimized by central composite design method.With appearance
solubility
emulsification time
particle size after emulsified and polydispersity coefficient as indexes to do quality evaluation of artemisinin emulsifying preparation.Result:Optimum prescription of this preparation was:MCT-tween-80-ethanol 31∶ 37∶ 20
it had uniform and transparent appearance
particle size was 234.7 nm
polydispersity coefficient 0.235
self-emulsifying time was 25 s
solubility was 2.775 g·L-1.Conclusion:Technology of arteannuin self-emulsifying preparation was simple and stable