The Effect of Bufei Capsule on Chronic Obstructive Pulmonary Diseases in Rat Model

HAN Yun-xia1; JIANG Ling1; QU Xiang-ling1; LI Ling2; WANG Cui-ru2

doi:10.13422/j.cnki.syfjx.2012.09.012

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The Effect of Bufei Capsule on Chronic Obstructive Pulmonary Diseases in Rat Model

更新时间：2024-09-23

- The Effect of Bufei Capsule on Chronic Obstructive Pulmonary Diseases in Rat Model
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 9, Pages: 210-213(2012)
- 作者机构：
  
  1. 贵阳中医学院第二附属医院药剂科
  2. 贵阳医学院机能学实验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.09.012
  CLC： R259
- Published：2012
- 稿件说明：
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[1]韩云霞,蒋玲,屈相玲,李玲,王翠茹.补肺胶囊对慢性阻塞性肺疾病动物模型的疗效观察[J].中国实验方剂学杂志,2012,18(09):210-213.

HAN Yun-xia1, JIANG Ling1, QU Xiang-ling1, et al. The Effect of Bufei Capsule on Chronic Obstructive Pulmonary Diseases in Rat Model[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 210-213.
[1]韩云霞,蒋玲,屈相玲,李玲,王翠茹.补肺胶囊对慢性阻塞性肺疾病动物模型的疗效观察[J].中国实验方剂学杂志,2012,18(09):210-213. DOI： 10.13422/j.cnki.syfjx.2012.09.012.

HAN Yun-xia1, JIANG Ling1, QU Xiang-ling1, et al. The Effect of Bufei Capsule on Chronic Obstructive Pulmonary Diseases in Rat Model[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 210-213. DOI： 10.13422/j.cnki.syfjx.2012.09.012.

摘要

目的:观察补肺胶囊对大鼠慢性阻塞性肺疾病（COPD）模型肺功能的影响以及其对COPD病程中主要临床症状的治疗效果。方法:取清洁级雄性SD大鼠

采用被动吸烟法（每天1次

每次30 min

连续32 d）

并于吸烟第1天和第16天时

采用气管滴注脂多糖（每只大鼠给予0.1%脂多糖水溶液200μL）的方法复制COPD大鼠模型

筛选造模成功的大鼠60只

按体重随机分为6组

即补肺胶囊高、中、低剂量组（2.1

1.05

0.53 g·kg-1）、模型组、氨茶碱阳性药组（氨茶碱60 mg·kg-1）和空白对照组。各实验组ig给药

每天给药1次

连续给药4周

对照组、模型组灌服同体积生理盐水

观察各组大鼠肺功能的改变情况;依次采用鼠耳肿胀法及碳粒廓清实验、氨水引咳法、组胺诱喘法及酚红法分别观察补肺胶囊的抗炎免疫调节、止咳、平喘及化痰作用。结果:与模型组比较

补肺胶囊组大鼠的0.3 s用力呼气量[FEV0.3

（3.715±0.399）mL

P<0.05]

0.3 s用力呼气量占用力肺活量FVC比值[FEV0.3/FVC（75.239±3.847）%

P<0.01]均升高

另外与空白对照组比较

补肺胶囊组的咳嗽潜伏期延长[（89.0±19.4）s

P<0.01]

而2 min咳嗽次数减少[（23±10）次

P<0.01]

鼠耳肿胀度也明显减轻、祛痰指数及廓清指数均显著增高（P<0.01）。结论:补肺胶囊能改善COPD模型大鼠的肺功能;并能有效改善贯穿COPD病程始终的各种临床表现。

Abstract

Objective: To observe the impact of bufei capsule on chronic obstructive pulmonary disease（COPD） in rats model.Method: The model of COPD was established by applying intra-tracheal injection of lipopdysaccharide（LPS） and smoking.The drugs was given by gavages for four weeks

and the changes of lung function was observed.The ear swelling method and the carbon clearance test

ammonia cited cough

histamine induced asthma method and phenol red method were used to observe the anti-inflammatory

immunity regulation and relieving cough

asthma and phlegm.Result: Compared with the model group

the indexes of forced expiratory volume in 0.3 seeond（FEV0.3）

forced vital capaeity（FVC）

FEV0.3/FVC and arterial pH

partial pressure of oxygen（PaO2） increased（P<0.01 or P<0.05）

and carbon dioxide partial pressure（PaCO2） decreased（P<0.01 or P<0.05） in the bufei capsule group.The relieving cough

asthma and phlegm anti-inflammatory effects and immunoregulation were more significant in bufei casule group than that in modle group.（P<0.01 or P<0.05）.Conclusion: The Bufei capsule can improve lung function and a variety of clinical manifestations in COPD.

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Related Author

HAN Yun-xia

JIANG Ling

QU Xiang-ling

LI Ling

WANG Cui-ru

YAN Yanan

LIANG Yulei

WANG Jiepeng

Related Institution

Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Lung Disease Research

Hebei University of Chinese Medicine

Affiliated Hospital，Shaanxi University of Chinese Medicine

Anhui College of TCM Respiratory Disease Prevention and Treatment Research Institute

Key Laboratory of TCM for the Prevention and Treatment of Major Pulmonary Diseases， Anhui Provincial Department of Education Key Laboratory

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