Quality Control of Zhisou Qingguo Pills

ZHANG Jian-wei1; WANG Rui-feng1; YANG Ai-gang1; LI Jun-hong1; XING Ya-nan1; ZHANG Si-ju2

doi:10.13422/j.cnki.syfjx.2012.09.022

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Quality Control of Zhisou Qingguo Pills

更新时间：2024-09-23

- Quality Control of Zhisou Qingguo Pills
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 9, Pages: 133-135(2012)
- 作者机构：
  
  1. 北京振东光明药物研究院有限公司国家中医药三级实验室
  2. 中国中医科学院中药研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.09.022
  CLC： R286
- Published：2012
- 稿件说明：
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[1]张建伟,王瑞峰,杨爱岗,李军红,邢亚楠,张思巨.止嗽青果丸质量控制[J].中国实验方剂学杂志,2012,18(09):133-135.

ZHANG Jian-wei1, WANG Rui-feng1, YANG Ai-gang1, et al. Quality Control of Zhisou Qingguo Pills[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 133-135.
[1]张建伟,王瑞峰,杨爱岗,李军红,邢亚楠,张思巨.止嗽青果丸质量控制[J].中国实验方剂学杂志,2012,18(09):133-135. DOI： 10.13422/j.cnki.syfjx.2012.09.022.

ZHANG Jian-wei1, WANG Rui-feng1, YANG Ai-gang1, et al. Quality Control of Zhisou Qingguo Pills[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 133-135. DOI： 10.13422/j.cnki.syfjx.2012.09.022.

摘要

目的:为了提高止嗽青果丸的质量标准

建立止嗽青果丸质量控制的定性与定量方法。方法:采用薄层色谱法对处方中西青果以甲苯-乙酸乙酯-甲酸（5∶4∶1）、麻黄以三氯甲烷-甲醇-浓氨水（20∶5∶0.5）为展开剂进行色谱鉴别;采用高效液相色谱法进行定量分析

以乙腈-0.1%磷酸溶液[5∶95（内含0.1%三乙胺）]为流动相

色谱柱kromasil-C18（4.6 mm×250mm

5μm）

流速0.8 mL·min-1

检测波长210 nm

柱温35℃。结果:薄层色谱图谱中能清晰检出西青果、麻黄;盐酸麻黄碱进样量在0.085～0.427 2μg线性关系良好（r=0.999 8）;平均回收率为95.88%

RSD 1.17%。结论:本方法专属性强

准确、简便

可作为止嗽青果丸的质量控制。

Abstract

Objective: For improving the quality level of Zhisou Qingguo pill

the qualitative and quantitative method for controlling the quality of Zhisou Qingguo pills was established.Method: Thin-layer chromatography was used for identifying the Fructus Terminaliae Immaturus which was developed with toluene-ethyl acetate-formic acid（5∶ 4∶ 1）

and ephedra developed with chloroform-methanol-strong ammonia（20∶ 5∶ 0.5）;HPLC method was used for quantitative analysis with Acetonitrile-0.1% phosphoric acid solution [5∶ 95（containing 0.1% triethylamine）] as mobile phase

the flow rate was 0.8 mL·min-1 flow rate

detection wavelength was at 210 nm and column temperature was at 350 ℃.Result: Fructus Terminaliae Immaturus and ephedra were clearly detected in Thin-layer chromatography atlas;Linear relationship was set up（r =0.999 8） within 0.085-0.427 2 μg as the sample size of Ephedrine hydrochloride;The average recovery was 95.88%;RSD was 1.17%.Conclusion: The method was exclusive

accurate

and simple

and it can be used for the quality control of Zhisou Qingguo pills.

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Related Author

ZHANG Jian-wei

WANG Rui-feng

YANG Ai-gang

LI Jun-hong

XING Ya-nan

ZHANG Si-ju

HAO Yadong

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Related Institution

Haidian District Food and Drug Safety Monitoring Center

China Academy of Chinese Medical Sciences

College of Pharmacy， Shaanxi University of Chinese Medicine

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Nanyang Medical College

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