Inhibition of Qiaojing Bushen Capsule on Intestinal Glucose Absorption in vitro

GAO Xiu-juan; MA Hui-xia; YAO Rong-mei; SUN Na; JIANG Chun-hua; LA Xiao-jin

doi:10.13422/j.cnki.syfjx.2012.09.043

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Inhibition of Qiaojing Bushen Capsule on Intestinal Glucose Absorption in vitro

更新时间：2024-09-23

- Inhibition of Qiaojing Bushen Capsule on Intestinal Glucose Absorption in vitro
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 9, Pages: 214-216(2012)
- 作者机构：
  
  河北联合大学中医学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.09.043
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]高秀娟,马会霞,姚荣妹,孙娜,江春花,喇孝瑾.荞精补肾胶囊对小肠葡萄糖吸收的体外抑制作用[J].中国实验方剂学杂志,2012,18(09):214-216.

GAO Xiu-juan, MA Hui-xia, YAO Rong-mei, et al. Inhibition of Qiaojing Bushen Capsule on Intestinal Glucose Absorption in vitro[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 214-216.
[1]高秀娟,马会霞,姚荣妹,孙娜,江春花,喇孝瑾.荞精补肾胶囊对小肠葡萄糖吸收的体外抑制作用[J].中国实验方剂学杂志,2012,18(09):214-216. DOI： 10.13422/j.cnki.syfjx.2012.09.043.

GAO Xiu-juan, MA Hui-xia, YAO Rong-mei, et al. Inhibition of Qiaojing Bushen Capsule on Intestinal Glucose Absorption in vitro[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 214-216. DOI： 10.13422/j.cnki.syfjx.2012.09.043.

摘要

目的:观察荞精补肾胶囊（QJBS）体外抑制小肠葡萄糖吸收的作用。方法:SD大鼠禁食不禁水24 h

处死

制备小肠离体外翻模型

随机分为空白对照组、阿卡波糖对照组（0.25 g·L-1）和QJBS 1～QJBS 5（2.5

5.0

10.0

20.0

40.0 g·L-1）。将肠囊分别放入等量的营养液中

加入麦芽糖及受试药物

在37℃水浴箱中孵育120 min

测定葡萄糖浓度并计算抑制率。结果:QJBS各组对离体小肠葡萄糖的吸收具有抑制作用

当药物质量浓度为20.0 g·L-1

抑制作用最明显

抑制率为（67.7±10.5）%

与阿卡波糖抑制作用相当。结论:QJBS能够抑制小肠对葡萄糖的吸收

其作用可能与抑制肠道α-糖苷酶类有关。

Abstract

Objective: To observe inhibition of Qiaojing Bushen capsules（QJBS） in vitro on glucose absorptionin small intestinal.Method: SD rats were fasted and gave water for 24 hours

then sacrificed to prepare small intestine in vitro everted model.Rats were divided into the blank control group

and acarbose tablets group 0.25 g·L-1 and QJBS group: QJBS 1-QJBS 5（2.5

5.0

10.0

20.0

40.0 g·L-1）.The sugar substrate and tested drugs were added into gut sac

which were incubated for 120 min at 37 ℃ to determin glucose concentrations

and the inhibition rate was calculated.Result:Each group of QJBS can inhibit small intestinal absorption of glucose

when the drug concentration was 20 g·L-1

inhibitory effect was the most obvious.The inhibition rat was（67.7±10.5）%

which was equal to acarbose.Conclusion: QJBS can inhibit intestinal glucose absorption

the effect may be related to inhibition of intestinal α-glucosidase.

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Related Author

LA Xiao-jin

JIANG Chun-hua

SUN Na

YAO Rong-mei

MA Hui-xia

GAO Xiu-juan

ZHU Baochen

LIU Wenhui

Related Institution

School of Chinese Materia Medica， Beijing University of Chinese Medicine

Dongzhimen Hospital， Beijing University of Chinese Medicine

Hospital of Chengdu University of Traditional Chinese Medicine

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