ZHANG Ye1, XIE Ming2, LIU Yue3. The Effect of 3 Kinds of Formulas with Different Therapeutic Methods on Hemorheology and ET-1 Level in Rats with Type 2 Diabetes Insulin Resistance[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 247-250.
ZHANG Ye1, XIE Ming2, LIU Yue3. The Effect of 3 Kinds of Formulas with Different Therapeutic Methods on Hemorheology and ET-1 Level in Rats with Type 2 Diabetes Insulin Resistance[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 247-250. DOI: 10.13422/j.cnki.syfjx.2012.09.051.
The Effect of 3 Kinds of Formulas with Different Therapeutic Methods on Hemorheology and ET-1 Level in Rats with Type 2 Diabetes Insulin Resistance
Objective: To investigate the effects of 3 kinds of formulas with different therapeutic methods on hemorheology and endothelin-1(ET-1) level in rats with type 2 diabetes mellitus(T2DM).Method: The rat model was established by feeding of high glucose and fat diet with peritoneal injection of(STZ).Different formulas were given to the modeling rats.Then indexes of
hemorheology and levels of ET-1 were tested.Result: Compared with the model group
the level of the whole blood viscosity at the 200 s-1
5 s-1 shear rate and plasma viscosity of theⅠformula(Yiqi Yangyin Huatan Huoxue fang) group and the Ⅲ formula(Huatan Jiangzhuo Huoxue Huayu fang) group were decreased obviously
the level of ET-1 of all formulas was decreased obviously.Conclusion:The effect of Ⅰformula(Yiqi Yangyin Huatan Huoxue fang) is the best among the 3 kinds of formulas.The Yiqi Yangyin Huatan Huoxue fang has an improvement effect on hemorheology and endothelial cell injury in rats with type 2 diabetes mellitus.
The Effect of 3 Kinds of Formulas with Different Therapeutic Methods on Hemorheology and ET-1 Level in Rats with Type 2 Diabetes Insulin Resistance
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Related Author
ZHANG Ye
XIE Ming
LIU Yue
TAN Danni
XIANG Qin
YU Yunfeng
YU Rong
XU Guangyuan
Related Institution
School of Traditional Chinese Medicine,Hunan University of Chinese Medicine
Fuxing Hospital of Capital Medical University
Gansu Key Laboratory for Excavation,Innovation,and Transformation of Traditional Chinese Medicine,Diabetes Laboratory,Gansu University of Chinese Medicine
Ningxia Medical University
Formula Department,Henan College of Traditional Chinese Medicine