Influence of Different Compatibility of Chaihu Shugan Powder on Dissolution of Saikosaponin a

WANG Lin-lin; WANG Chun-yan; ZHANG Dan-shen; ZHANG Wan-ming; WANG Zhi-bao

doi:10.13422/j.cnki.syfjx.2012.09.063

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Influence of Different Compatibility of Chaihu Shugan Powder on Dissolution of Saikosaponin a

更新时间：2024-09-23

- Influence of Different Compatibility of Chaihu Shugan Powder on Dissolution of Saikosaponin a
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 9, Pages: 46-49(2012)
- 作者机构：
  
  河北北方学院药学系
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.09.063
  CLC： R284.2
- Published：2012
- 稿件说明：
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[1]王林林,王春艳,张丹参,张万明,王治宝.柴胡疏肝散不同配伍对柴胡皂苷a溶出量的影响[J].中国实验方剂学杂志,2012,18(09):46-49.

WANG Lin-lin, WANG Chun-yan, ZHANG Dan-shen, et al. Influence of Different Compatibility of Chaihu Shugan Powder on Dissolution of Saikosaponin a[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 46-49.
[1]王林林,王春艳,张丹参,张万明,王治宝.柴胡疏肝散不同配伍对柴胡皂苷a溶出量的影响[J].中国实验方剂学杂志,2012,18(09):46-49. DOI： 10.13422/j.cnki.syfjx.2012.09.063.

WANG Lin-lin, WANG Chun-yan, ZHANG Dan-shen, et al. Influence of Different Compatibility of Chaihu Shugan Powder on Dissolution of Saikosaponin a[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 46-49. DOI： 10.13422/j.cnki.syfjx.2012.09.063.

摘要

目的:研究柴胡疏肝散不同配伍对柴胡皂苷a溶出量的影响。方法:采用L8（27）正交设计法

以HPLC-DAD测定各配伍样品中柴胡皂苷a的含量

并对数据进行单因素方差分析。结果:正交设计各因素对柴胡皂苷a溶出率的影响大小为使药>佐药>臣药。单因素对其影响均有显著性差异

交互作用无显著性差异。4组分法中

各组间均有显著性差异。不同药味数分组中

各大组之内不同配伍柴胡皂苷a溶出率不同

各组间溶出率:复方>五五配伍>单煎液>六六配伍、两两配伍>四四配伍>三三配伍。结论:含有白芍、香附、川芎的配伍组中柴胡皂苷a的溶出率较低

含有枳壳和甘草配伍组中柴胡皂苷a的溶出率较高

全方组中柴胡皂苷a的溶出率最高。

Abstract

Objective: To study on influence of different compatibility of Chaihu Shugan powder on dissolution of saikosaponin a.Method: L8（27） orthogonal design method was used with determining the content of saikosaponin a in each compatibility samples by HPLC/DAD

and data was analyzed by single-factor variance analysis.Result: Influence degree of every factors in orthogonal test on dissolution of saikosaponin a was:guide> adjuvant> associate.Effect of it（dissolution of saikosaponin a） had significant difference by single-factor

but there was no significant difference in interaction.It had significant difference among groups in the 4 groups classified.In the different number of drugs classified

dissolution of saikosaponin a was different in every major groups with different compatibility

dissolution rates among every groups:the compound group> five-five compatibility group> single-decoction group> six-six compatibility group

two-two compatibility group> four-four compatibility group> three-three compatibility group.Conclusion: Dissolution of saikosaponin a was lower from groups including Radix Paeoniae Alba

Rhizoma Cyperi and Rhizoma Chuanxiong

it was higher from groups including Auranti Fructus and Glycyrrhiza Uralensis

it was the highest from the compound group.

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Related Author

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ZHANG Wan-ming

WANG Zhi-bao

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Related Institution

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Affiliated Hospital of Shandong University of Traditional Chinese Medicine

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