Influence of Body Weight on Urine Albumin Levels Detected in Experimental Diabetic Nephropathy Rats

ZHOU Shu-hong1; LV Hong-jun1; SHI Bing-yin1; CUI Bo1; XU Li1

doi:10.13422/j.cnki.syfjx.2012.09.086

您当前的位置：

首页 >

文章列表页 >

Influence of Body Weight on Urine Albumin Levels Detected in Experimental Diabetic Nephropathy Rats

更新时间：2024-09-23

- Influence of Body Weight on Urine Albumin Levels Detected in Experimental Diabetic Nephropathy Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 9, Pages: 266-269(2012)
- 作者机构：
  
  1. 西安交通大学医学院第一附属医院内分泌科
  2. 甘肃省人民医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.09.086
  CLC： R587.2;R692.9
- Published：2012
- 稿件说明：
移动端阅览
[1]周淑红,吕宏军,施秉银,崔波,徐利.体重对糖尿病肾病大鼠尿蛋白检测的影响分析[J].中国实验方剂学杂志,2012,18(09):266-269.

ZHOU Shu-hong1, LV Hong-jun1, SHI Bing-yin1, et al. Influence of Body Weight on Urine Albumin Levels Detected in Experimental Diabetic Nephropathy Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 266-269.
[1]周淑红,吕宏军,施秉银,崔波,徐利.体重对糖尿病肾病大鼠尿蛋白检测的影响分析[J].中国实验方剂学杂志,2012,18(09):266-269. DOI： 10.13422/j.cnki.syfjx.2012.09.086.

ZHOU Shu-hong1, LV Hong-jun1, SHI Bing-yin1, et al. Influence of Body Weight on Urine Albumin Levels Detected in Experimental Diabetic Nephropathy Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 266-269. DOI： 10.13422/j.cnki.syfjx.2012.09.086.

摘要

目的:探讨体重对实验性糖尿病肾病大鼠尿蛋白检测的影响。方法:清洁级健康雄性SD大鼠72只

随机分为糖尿病组（DM组

n=45）和对照组（NC组

n=27）

糖尿病组大鼠一次性腹腔注射STZ 60 mg.kg-1。两组大鼠分别在第4

16周留取24 h尿液

用放免法检测尿白蛋白

监测体重（BW）

同时检测肾脏功能和形态。结果:尿白蛋白/肌酐（UACR）在两组间无差异于;尿白蛋白（UTP）

尿白蛋白排泄率（UAER）

UTP/BW

UAER/BW

UACR/BW在4个时间点DM组高于NC组（P<0.05）;5种尿蛋白不同评价指标与肾脏功能形态指标无相关性。结论:体重对糖尿病大鼠UACR的指标评价影响最明显。5种尿白蛋白的评价指标在糖尿病肾病早期不能动态完全反映肾脏病理损害变化。

Abstract

Objective:To compare the influence of body weight in diagnostic importance for experimental diabetic nephropathy rats among three urinary protein screening methods.Method: Seventy-two SPF male Sprague-dawley rats were randomLy divided into control group（NC

n=27） and diabetic group（DM

n=45）

which were induced with streptozotocin once intraperitoneal injection.At 4

16 w after injection

the 24 h urine albumin levels were measured by immunoturbidime-try.The body weight and general renal function index were monitored and the tissue sections of renal were examined with lightmicroscopy.Result:The levels of UTP

UAER

UTP/BW

UAER/BW and UACR/BW were higher in diabetic rats than that of the normal group（P<0.05）

but there was no difference in UACR between the two groups.There was no correlation between the levels of the five different urinary albumin screening methods and renal-related indicators in diabetic rats.Conclusion: These data indicate that the body weight only affect the diagnostic importance of UACR and the five different urinary albumin screening methods could not be a perfect marker in diagnosis of diabetic early-stage nephropathy and indicator of the developing process of glomerulosclerosis.

关键词

Keywords

references

Views

153

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Influence of Body Weight on Urine Albumin Levels Detected in Experimental Diabetic Nephropathy Rats

Effect of Keyushushen Granule on Weight and Behavior of Experimental Dysthymia Rat

Preventive Effect of Salidroside on Stressed Mice Induced by Repeated Tail Suspension Test

Effect of Conjugated Linoleic Acid,Magensium and Selenium on Body Weight Reduction in Mice Fed by High-Fat Diet

Related Author

ZHOU Shu-hong

LV Hong-jun

SHI Bing-yin

CUI Bo

XU Li

ZHANG Mao-yun1

GAO Bo2

WANG Jian1

Related Institution

Institute of Geographical Sciences and Natural Resources Research CAS

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰