Simiao Yongan Decoction on Qi Stagnancy and Blood Stasis in Patients of 30 Cases with Chronic Heart Failure

ZHOU Ling-yun; LOU Jin-bo; HU Xian-jue; XIANG Yong-jing; FU Rong

doi:10.13422/j.cnki.syfjx.2012.15.009

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Simiao Yongan Decoction on Qi Stagnancy and Blood Stasis in Patients of 30 Cases with Chronic Heart Failure

更新时间：2024-09-23

- Simiao Yongan Decoction on Qi Stagnancy and Blood Stasis in Patients of 30 Cases with Chronic Heart Failure
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 15, Pages: 270-272(2012)
- 作者机构：
  
  贵阳中医学院第二附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.15.009
  CLC： R259
- Published：2012
- 稿件说明：
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[1]周凌云,娄金波,胡先觉,项永晶,付蓉.加味四妙勇安汤治疗气滞血瘀证慢性心力衰竭患者30例[J].中国实验方剂学杂志,2012,18(15):270-272.

ZHOU Ling-yun, LOU Jin-bo, HU Xian-jue, et al. Simiao Yongan Decoction on Qi Stagnancy and Blood Stasis in Patients of 30 Cases with Chronic Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 270-272.
[1]周凌云,娄金波,胡先觉,项永晶,付蓉.加味四妙勇安汤治疗气滞血瘀证慢性心力衰竭患者30例[J].中国实验方剂学杂志,2012,18(15):270-272. DOI： 10.13422/j.cnki.syfjx.2012.15.009.

ZHOU Ling-yun, LOU Jin-bo, HU Xian-jue, et al. Simiao Yongan Decoction on Qi Stagnancy and Blood Stasis in Patients of 30 Cases with Chronic Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 270-272. DOI： 10.13422/j.cnki.syfjx.2012.15.009.

摘要

目的:观察四妙勇安汤加味对气滞血瘀型慢性心力衰竭患者的临床疗效

并探讨其作用机制。方法:将60例气滞血瘀型慢性心力衰竭患者随机分为观察组、对照组各30例。两组患者均给予阿司匹林肠溶片

口服

100 mg/次

1次/d;阿托伐他汀片

口服

20 mg/次

1次/d。观察组在对照组治疗基础上给予四妙勇安汤加味

水煎服

1剂/d。两组均以4周为1个疗程

间隔1周

开始第2个疗程

共4个疗程。结果:临床治愈率观察组57.50%

对照组40.00%

总有效率观察组95.00%

对照组75.00%

两组差异显著（P<0.05）。治疗后全血高切黏度、全血中切黏度、全血低切黏度、血浆黏度、红细胞压积观察组分别为[（3.52±0.62）

（4.33±0.54）

（7.18±1.55）

（1.32±0.14）mPa.s

（34.43±5.54）%]

对照组分别为[（3.72±0.58）

（44.52±0.64）

（7.41±1.23）

（1.41±0.15）mPa.s

（36.78±5.68）%]

两组治疗后与治疗前比有明显下降（P<0.05）

治疗后观察组改善优于对照组（P<0.05）。血清TC

LDL-C

HDL-C观察组分别为（3.62±1.60）

（2.32±1.54）

（3.15±1.55）

（1.92±0.14）mmol·L-1

对照组分别为（4.75±1.58）

（3.32±1.64）

（4.31±1.23）（1.56±0.15）mmol·L-1

两组治疗后与治疗前比有明显下降（P<0.05）

治疗后观察组改善优于对照组（P<0.05）。结论:四妙勇安汤加味对气滞血瘀型慢性心力衰竭临床疗效显著

其作用机制与影响血液流变性及血脂各项指标有关。

Abstract

Objective: To observe the Simiao Yongan decoction on qi stagnancy and blood stasis syndrome in patients with chronic heart failure and to explore the related mechanism.Method: Cases of stagnancy of Qi and blood stasis with chronic heart failure were randomly divided into the observation group

the control group

with 30 cases in each group.Two groups of patients were given aspirin enteric-coated tablets

oral

100 mg daily;atorvastatin tablets

oral

20 mg daily.In the observation group based on the treatment of control group given Simiao Yongan decoction.The two groups were daily 4 weeks as 1 course.An interval of 1 week

was scheduled before starting second course.The total treatment lasted 4 courses.Result: The clinical cure rate was observed in observation group 57.50%

control group 40%（P<0.05）.The total efficiency of the observation group was 95%

control group 75%（P<0.05）.After treatment of high shear viscosity of whole blood

blood middle shear viscosity

blood low shear viscosity

plasma viscosity

hematocrit in observation group were（3.52±0.62）

（4.33±0.54）

（7.18±1.55）

（1.32±0.14）mPa·s

（34.43±5.54）%

compared to the control group respectively（3.72±0.58）

（4.52±0.64）

（7.41±1.23）

（1.41±0.15）mPa·s

（36.78±5.68）%

（P<0.05）.After treatment

the observation group was better than the control group（P<0.05）.TC

LDL-C

HDL-C group respectively（3.62±1.60）

（2.32±1.54）

（3.15±1.55）

（1.92±0.14） mmol·L-1

the control group respectively（4.75±1.58）（3.32±1.64）（4.31±1.23）（1.56±0.15） mmol·L-1

（P<0.05）.After treatment

the observation group was better than control group（P<0.05）.Conclusion:Clinical curative effect of Simiao Yongan decoction on qi stagnancy and blood stasis syndrome of chronic heart failure is significant.Its mechanism may be related to effect on hemorheology and blood lipids indicators concerned.

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Related Author

ZHOU Ling-yun

LOU Jin-bo

HU Xian-jue

XIANG Yong-jing

FU Rong

WANG Guojun

ZHANG Shimin

JIN Jiao

Related Institution

Wangjing Hospital of China Academy of Chinese Medical Sciences

Wangjing Hospital of Chinese Academy of Chinese Medicine Sciences

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State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs， Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences

Jiangxi Province Key Laboratory of Traditional Chinese Medicine（TCM） Pharmacology，Institute of TCM Health Industry，China Academy of Chinese Medical Sciences

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