Effect of Yiqi Yangyin Huazhuo Tongluo Recipe on Plasma TGF-β<sub>1</sub>,MMP-9 and TIMP-1 in Patients with Early Diabetic Nephropathy

LV Qin1; BIAN Hua2; HAN Di1; CAI Wen3; CHEN Zhi-guo2; HU Jiu-lue2

doi:10.13422/j.cnki.syfjx.2012.15.010

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Effect of Yiqi Yangyin Huazhuo Tongluo Recipe on Plasma TGF-β₁,MMP-9 and TIMP-1 in Patients with Early Diabetic Nephropathy

更新时间：2024-09-23

- Effect of Yiqi Yangyin Huazhuo Tongluo Recipe on Plasma TGF-β₁,MMP-9 and TIMP-1 in Patients with Early Diabetic Nephropathy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 15, Pages: 287-290(2012)
- 作者机构：
  
  1. 南阳医学高等专科学校
  2. 南阳理工学院张仲景国医学院
  3. 南阳市中医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.15.010
  CLC： R259;R277.5
- Published：2012
- 稿件说明：
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[1]吕芹,卞华,韩迪,蔡文,陈志国,胡久略.益气养阴化浊通络方对早期糖尿病肾病患者TGF-β_1,MMP-9,TIMP-1表达的影响[J].中国实验方剂学杂志,2012,18(15):287-290.

LV Qin1, BIAN Hua2, HAN Di1, et al. Effect of Yiqi Yangyin Huazhuo Tongluo Recipe on Plasma TGF-β₁,MMP-9 and TIMP-1 in Patients with Early Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 287-290.
[1]吕芹,卞华,韩迪,蔡文,陈志国,胡久略.益气养阴化浊通络方对早期糖尿病肾病患者TGF-β_1,MMP-9,TIMP-1表达的影响[J].中国实验方剂学杂志,2012,18(15):287-290. DOI： 10.13422/j.cnki.syfjx.2012.15.010.

LV Qin1, BIAN Hua2, HAN Di1, et al. Effect of Yiqi Yangyin Huazhuo Tongluo Recipe on Plasma TGF-β₁,MMP-9 and TIMP-1 in Patients with Early Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 287-290. DOI： 10.13422/j.cnki.syfjx.2012.15.010.

摘要

目的:探讨益气养阴化浊通络方对早期糖尿病肾病（DN）患者血清转化生长因子β1（TGF-β1）、基质金属蛋白酶-9（MMP-9）、组织型金属蛋白酶抑制剂-1（TIMP-1）表达水平的影响。方法:63例早期DN患者随机分组

对照组（31例）采用DN常规治疗

治疗组（32例）在常规治疗基础上加用益气养阴化浊通络方

疗程3个月。采用酶联免疫吸附法（ELISA）测定两组患者治疗前后血清TGF-β1

MMP-9

TIMP-1水平

同时观察β2-微球蛋白（β2-MG）、尿微量白蛋白排泄率（UAER）的变化。结果:与治疗前比较

两组患者治疗后TGF-β1

TIMP-1水平下降（P<0.05

P<0.01）

MMP-9水平、MMP/TIMP-1比值升高（P<0.05

P<0.01）

β2-MG

UAER指标改善（P<0.05

P<0.01）。同时治疗组治疗后TGF-β1

MMP-9

TIMP-1及Ⅳ型胶原水平改善优于对照组（P<0.05

P<0.01）。结论:益气养阴化浊通络方可能是通过改善血清TGF-β1

MMP-9

TIMP-1水平而影响细胞外基质（ECM）代谢调控系统

延缓DN的进展。

Abstract

Objective: To investigate the effect of Yiqi Yangyin Huazhuo Tongluo recipe（YQYYHZTLR） on plasma transforming growth factor beta1（TGF-β1）

matrix metalloproteinase-9（MMP-9）

tissue inhibitor of metalloproteinase-1（TIMP-1） in patients with early diabetic nephropathy（DN）.Method: Sixty-three patients with DN were randomly divided into the control group（n=31） and the treatment group（n=32）.The control group was applied DN regular treatment and the treatment group was added to YQYYHZTLR on the basis of regular treatment.Both of them were treated for three months.Plasma TGF-β1

MMP-9

and TIMP-1 were determined with ELISA in two groups both before and after treatment.β2-microglobulin（β2-MG）and urinary albumin excretion rate（UAER） were also examined.Result: Plasma levels of TGF-β1and TIMP-1 between the two groups were significantly lower than those of pretreatment（P<0.05

P<0.01）.Plasma levels of MMP-9 and MMP/TIMP-1 rate between the two groups were significantly higher than those of pretreatment（P<0.05

P<0.01）.Favorable changes of levels of other parameters（β2-MG and UAER） were also demonstrated（P<0.05

P<0.01）.At the same time

plasma levels of TGF-β1

MMP-9 and TIMP-1 were different significantly in the treatment group after treatment compared to the control group（P<0.05

P<0.01）.Conclusion: YQYYHZTLR has a strong influence on regulation and control of extracellular matrix（ECM） metabolism to delay the development of early DN by improving plasma levels of TGF-β1

MMP-9 and TIMP-1.

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Related Author

LV Qin

HU Jiu-lue

CHEN Zhi-guo

CAI Wen

HAN Di

BIAN Hua

CAI Wen

LI Wanzhe

Related Institution

Graduate School， Hebei University of Chinese Medicine

The First Affiliated Hospital of Hebei University of Chinese Medicine，Hebei Provincial Hospital of Traditional Chinese Medicine

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Effect of Yiqi Yangyin Huazhuo Tongluo Recipe on Plasma TGF-β1,MMP-9 and TIMP-1 in Patients with Early Diabetic Nephropathy

DOI：10.13422/j.cnki.syfjx.2012.15.010

摘要

Abstract

关键词

Keywords

references

Effect of Yiqi Yangyin Huazhuo Tongluo Recipe on Plasma TGF-β₁,MMP-9 and TIMP-1 in Patients with Early Diabetic Nephropathy