Influence of Angelica dahurica and Acorus tatarinowii on Transdermal Permeation Role of Active Ingredients from Chonghe Gel Prescription

WANG Ya-jing; SUN Shi-zhen; ZHANG De-qin; TIAN Hui; PENG Shu-juan; WANG Yan-ming

doi:10.13422/j.cnki.syfjx.2012.15.024

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Influence of Angelica dahurica and Acorus tatarinowii on Transdermal Permeation Role of Active Ingredients from Chonghe Gel Prescription

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- Influence of Angelica dahurica and Acorus tatarinowii on Transdermal Permeation Role of Active Ingredients from Chonghe Gel Prescription
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 15, Pages: 38-41(2012)
- 作者机构：
  
  天津中医药大学天津市现代中药重点实验室-省部共建国家重点实验室培育基地
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.15.024
  CLC： R284
- Published：2012
- 稿件说明：
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[1]王亚静,孙士真,张德芹,田慧,彭淑娟,王艳明.白芷、石菖蒲对冲和膏处方中主要成分经皮渗透作用的影响[J].中国实验方剂学杂志,2012,18(15):38-41.

WANG Ya-jing, SUN Shi-zhen, ZHANG De-qin, et al. Influence of Angelica dahurica and Acorus tatarinowii on Transdermal Permeation Role of Active Ingredients from Chonghe Gel Prescription[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 38-41.
[1]王亚静,孙士真,张德芹,田慧,彭淑娟,王艳明.白芷、石菖蒲对冲和膏处方中主要成分经皮渗透作用的影响[J].中国实验方剂学杂志,2012,18(15):38-41. DOI： 10.13422/j.cnki.syfjx.2012.15.024.

WANG Ya-jing, SUN Shi-zhen, ZHANG De-qin, et al. Influence of Angelica dahurica and Acorus tatarinowii on Transdermal Permeation Role of Active Ingredients from Chonghe Gel Prescription[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 38-41. DOI： 10.13422/j.cnki.syfjx.2012.15.024.

摘要

目的:考察佐使药白芷、石菖蒲对冲和膏中主要成分经皮渗透的影响。方法:采用改良Franz透皮扩散池

大鼠离体皮肤为渗透屏障

以芍药苷和蛇床子素为指标

HPLC测定其含量

分别考察白芷、石菖蒲及其配伍联用对冲和膏主要成分促透作用的影响。结果:白芷、石菖蒲单用对芍药苷经皮渗透的增渗倍数分别为0.84

1.02

对蛇床子素的增渗倍数分别为1.54

0.79;配伍联用后芍药苷和蛇床子素的经皮渗透均达到最佳水平

增渗倍数分别1.00

1.89。结论:白芷、石菖蒲配伍联用可促进主要成分的经皮渗透

对冲和膏处方药效的发挥具有重要的佐使作用。

Abstract

Objective: To investigate effect of Angelica dahurica and Acorus tatarinowii on in vitro percutaneous permeation of active ingredients from Chonghe gel.Method: Improved Franz-type diffusion cell was used

with isolated rat skin as transdermal barrier

with the content of paeoniflorin and osthole as indexes which was determined by HPLC

effect of A.dahurica

A.tatarinowii alone and their compatibility combination on promote transparent role of main ingredients from Chonghe gel were investigated

respectively.Result: Enhancement ratios（ER） of A.dahurica and A.tatarinowii alone on percutaneous penetration of peoniflorin were 0.84

1.02

while ER of osthole were 1.54

0.79.Percutaneous penetration role of peoniflorin and osthole by compatibility combination of A.dahurica and A.tatarinowii could reach optimum level

ER of peoniflorin and osthole were 1.00

1.89.Conclusion: A.dahurica and A.tatarinowii used jointly could benefit to transdermal permeation of active ingredients

which had important role on therapeutic effect of Chonghe gel.

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Related Author

WANG Ya-jing

SUN Shi-zhen

ZHANG De-qin

TIAN Hui

PENG Shu-juan

WANG Yan-ming

DENG Dongjie

LI Li

Related Institution

Pharmacy Faculty， Hubei University of Chinese Medicine

Key Laboratory of Chinese Medicine Resource and Compound Prescription， Hubei University of Chinese Medicine

Jiangxi University of Traditional Chinese Medicine ( TCM)

Jiangxi College of TCM

School of Chinese Material Medica,Beijing University of Chinese Medicine

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