Determination of Notoginsenoside R1,Ginsenoside Rg1 and Rb1 in Qigui Drop Pill by HPLC

LI Zhong-wen; CHEN Long-hua

doi:10.13422/j.cnki.syfjx.2012.15.043

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Determination of Notoginsenoside R₁,Ginsenoside Rg₁ and Rb₁ in Qigui Drop Pill by HPLC

更新时间：2024-09-23

- Determination of Notoginsenoside R₁,Ginsenoside Rg₁ and Rb₁ in Qigui Drop Pill by HPLC
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 15, Pages: 112-116(2012)
- 作者机构：
  
  山东医学高等专科学校
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.15.043
  CLC： R286.0
- Published：2012
- 稿件说明：
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[1]李中文,陈龙华.HPLC测定七归滴丸中阿魏酸、三七皂苷R_1、人参皂苷Rg_1、人参皂苷Rb_1的含量[J].中国实验方剂学杂志,2012,18(15):112-116.

LI Zhong-wen, CHEN Long-hua. Determination of Notoginsenoside R₁,Ginsenoside Rg₁ and Rb₁ in Qigui Drop Pill by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 112-116.
[1]李中文,陈龙华.HPLC测定七归滴丸中阿魏酸、三七皂苷R_1、人参皂苷Rg_1、人参皂苷Rb_1的含量[J].中国实验方剂学杂志,2012,18(15):112-116. DOI： 10.13422/j.cnki.syfjx.2012.15.043.

LI Zhong-wen, CHEN Long-hua. Determination of Notoginsenoside R₁,Ginsenoside Rg₁ and Rb₁ in Qigui Drop Pill by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 112-116. DOI： 10.13422/j.cnki.syfjx.2012.15.043.

摘要

目的:建立测定七归滴丸中阿魏酸、三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1的含量测定方法。方法:采用C18柱（4.6 mm×150 mm

5μm）

流动相为甲醇-0.6%冰醋酸（30∶70）

检测波长为323 nm

测定阿魏酸;采用C18柱（4.6 mm×250 mm

5μm）

乙腈-水梯度洗脱

流速0.8 mL·min-1

检测波长203 nm

测定三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1。结果:阿魏酸的回收率为99.18%（RSD 1.4%）;三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1的回收率分别为98.77%（RSD1.71%）

98.94%（RSD 1.58%）

99.48%（RSD 1.65%）。结论:此法准确、可靠

重复性好

可用于控制七归滴丸的质量。

Abstract

Objective: To develop a method for the determination of ferulic acid

notoginsenoside R1

ginsenoside Rg1 and Rb1 in Qigui drop pill by HPLC.Method: The content of ferulic acid was quantified by HPLC.A C18 column was used with the mobile phase of methanol-0.6% glacial acetic acid solution（30∶ 70）

at the detection wavelength of 323 nm.The content of sanchi notoginsenoside R1

ginsenoside Rg1 and Rb1 was quantified by HPLC.A C18 column was used with the mobile phase of acetonitrile-water gradient elution.Equilibrium was 0.8 min and the wavelength of detector was set at 203 nm.Result: The average recovery of ferulic acid was 99.18%（RSD 1.4%）.The average recoveries of notoginsenoside R1

ginsenoside Rg1 and Rb1 were 98.77%（RSD 1.71%）

98.94%（RSD 1.58%） and 99.48%（RSD 1.65%）.Conclusion: The method is accurate

reliable and reproducible.It can be used for the quality control of Qigui drop pill.

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