SUI Feng1, YAN Mei-juan2, LIN Na1, et al. Comparative Study on Antipyretic Effects and its Mechanisms by Four Processed Rhei Radix et Rhizoma Products[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 167-170.
SUI Feng1, YAN Mei-juan2, LIN Na1, et al. Comparative Study on Antipyretic Effects and its Mechanisms by Four Processed Rhei Radix et Rhizoma Products[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 167-170. DOI: 10.13422/j.cnki.syfjx.2012.15.054.
Comparative Study on Antipyretic Effects and its Mechanisms by Four Processed Rhei Radix et Rhizoma Products
Objective: To investigate and compare the antipyretic effect of different processed rhubarb products as well as the mechanism of their antipyretic effect.Method: SD rats were given subcutaneous injection of dry yeast and treated with the processed rhubarb products an hour later.And then anal temperatures of the rats were measured at the 1st
2nd
4th and 6th hour
respectively.Radioimmunoassay was adopted to detect the level of cyclic adenosine monophosphate(cAMP) in the hypothalamus of rats.Result: All the processed rhubarb products could lower the rised body temperature to a certain degree and the effect duration could last more than 4 hours.Regarding the effects of all the processed products
the wine-cooked and crude rhubarb showed stronger action than the other two processed products of rhubarb.The correlation analysis further showed that content of cAMP in hypothalamus was positively correlated with the change of body temperature of rats.Conclusion: All the processed rhubarb products have antipyretic effects and their antipyretic mechanisms may be associated with lowering the increased content of cAMP in hypothalamus.
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Related Author
SUI Feng
YAN Mei-juan
LIN Na
XIAO Yong-qing
LI Li
HU Meibian
GAO Kuixu
WANG Yao
Related Institution
School of Pharmacy,Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province,Chengdu University
School of Traditional Chinese Medicine(TCM) and Food Engineering,Shanxi Provincial Key Laboratory of TCM Processing,Shanxi University of Chinese Medicine
Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province and Ministry of Education,Henan Engineering Research Center of Chinese Traditional Medicine Special Processing Technology,School of Pharmacy, Henan University of Chinese Medicine
Engineering Technology Research Center for Chinese Materia Medica Quality of Universities in Guangdong Province,Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica, National Administration of Traditional Chinese Medicine (TCM),School of TCM, Guangdong Pharmaceutical University
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences