CHUN Chun-wei, CHEN Ji-ting. Effect of Jiawei Yiguan Jian on Hepatic Injury in Rats Induced by Antituberculosis Drugs[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 201-204.
CHUN Chun-wei, CHEN Ji-ting. Effect of Jiawei Yiguan Jian on Hepatic Injury in Rats Induced by Antituberculosis Drugs[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 201-204. DOI: 10.13422/j.cnki.syfjx.2012.15.062.
Effect of Jiawei Yiguan Jian on Hepatic Injury in Rats Induced by Antituberculosis Drugs
Objective :To observe the effect of Jiawei Yiguan Jian on hepatic injury in rats induced by antituberculosis drugs isoniazid(INH) and rifampin(RFP).Method: The hepatic injury model rats were induced by intragastric administration with RFP and intraabdominal cavity administration with INH.Jiawei Yigan Jian decoction(high dose
medium dose and low dose 25.2
18.0
12.6 g·kg-1
ig)was given to the toxic rats respectively for 8 weeks.The general condition of rats
content of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in serum
content of malondialdehyde(MDA) in liver
histopathologic changes of liver were detected.Result: The content of ALT
AST in serum and MDA in liver tissue of the three treatment groups were decreased obviously.The extent of hepatic injury under light microscope was obviously improved.Conclusion: Jiawei Yiguan Jian can ameliorate the hepatic injury induced by antituberculosis drugs INH and RFP.
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Related Author
CHUN Chun-wei
CHEN Ji-ting
LI Wenjing
WANG Zhongyu
HUANG Yongxin
XU Jingjing
DING Ying
WU You
Related Institution
Key Laboratory of Health Cultivation of the Ministry of Education, Key Laboratory of Health Cultivation of Beijing, Beijing University of Chinese Medicine
Beijing Xiaotangshan Hospital
Institute of Chinese Medicine Health Preservation, Beijing University of Chinese Medicine
Science and Technology Office, Beijing University of Chinese Medicine
Disciplinary Innovation Base of the Ministry of Education