Effects of Compound Cordyceps militaris on Immune Function in C57BL/6 Tumor Bearing Mice

JI Xi-zhong; NING Qing; TAN Wei; ZHANG Run-tong; SONG Jie

doi:10.13422/j.cnki.syfjx.2012.15.068

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Effects of Compound Cordyceps militaris on Immune Function in C57BL/6 Tumor Bearing Mice

更新时间：2024-09-23

- Effects of Compound Cordyceps militaris on Immune Function in C57BL/6 Tumor Bearing Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 15, Pages: 227-230(2012)
- 作者机构：
  
  江苏省中医药研究院中药新型给药系统重点实验室/国家中医药管理局中药口服释药系统重点研究室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.15.068
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]季锡中,宁青,谈唯,张润桐,宋捷.复方蛹虫草制剂对C57BL/6荷瘤小鼠免疫功能的影响[J].中国实验方剂学杂志,2012,18(15):227-230.

JI Xi-zhong, NING Qing, TAN Wei, et al. Effects of Compound Cordyceps militaris on Immune Function in C57BL/6 Tumor Bearing Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 227-230.
[1]季锡中,宁青,谈唯,张润桐,宋捷.复方蛹虫草制剂对C57BL/6荷瘤小鼠免疫功能的影响[J].中国实验方剂学杂志,2012,18(15):227-230. DOI： 10.13422/j.cnki.syfjx.2012.15.068.

JI Xi-zhong, NING Qing, TAN Wei, et al. Effects of Compound Cordyceps militaris on Immune Function in C57BL/6 Tumor Bearing Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 227-230. DOI： 10.13422/j.cnki.syfjx.2012.15.068.

摘要

目的:研究蛹虫草复方制剂（CCM）对C57BL/6荷瘤小鼠免疫功能影响。方法:C57BL/6雄性小鼠腋下皮下注入Lewis肺癌小鼠移植瘤动物模型

将荷瘤鼠分为模型组、阳性对照组以环磷酰胺ip 20 mg·kg-1

复方蛹虫草制剂低、中、高剂量组（1.2

2.5

7.5）g·kg-1ig给药

连续给药14 d

以抑瘤率为指标考察CCM的体内抗肿瘤活性

分别测定其抑瘤率、T淋巴细胞亚群CD4+/CD8+;荷瘤小鼠血清中白细胞介素-2（IL-2）、白细胞介素-12（IL-12）、肿瘤坏死因子-α（TNF-α）水平;抗体生成细胞数以及力竭游泳时间。结果:CCM高剂量组(7.5 g·kg-1对肿瘤生长有明显的抑制作用（P<0.05）

其抑瘤率为40.3%

CCM高剂量组T淋巴细胞亚群CD3+

CD4+

CD4+/CD8+均高于模型对照组;同时中、高剂量组能显著提高荷瘤小鼠血清TNF-α

IL-2

IL-12的水平;抗体生成细胞数和力竭游泳时间也均高于荷瘤对照组（P<0.05）。结论:CCM具有提高荷瘤小鼠免疫功能的作用。

Abstract

Objective: To study the effects of compoun Dcordyceps militaris（CCM） on immune function in C57BL/6 tumor bearing mice.Method: Transplanted Lewis tumor mice were established using subcutaneous injection of Lewis cells into C57BL/6 mice.C57BL/6 tumor bearing mice were randomly divided into five groups

namely

control group and positive group（cyclophosphamide ip 20 mg·kg-1）

the low

middle and high dosage groups（ig 1.2

2.5

7.5 g·kg-1） for 14 constitutive days.The tumor inhibition rate

CD4+/CD8+ ratio

contents of interleukin（IL）-2

IL-12 and tumor necrosis factor-α（TNF-α） in tumor bearing mice serum

antibody-producing cells and forced swimming time were respectively determined.Result: CCM（7.5 g·kg-1）

orally administered

had a significant inhibitory action on the growth of tumor

with the inhibition rate as 40.3%（P<0.05）.CCM（7.5 g·kg-1） also improved CD3+

CD4+

CD4+/CD8+ ratio compared with the control group.Meanwhile

CCM（2.5

7.5 g·kg-1） enhanced the content of IL-2

IL-12 and TNF-α level

forced swimming time and antibody-producing cells（P<0.05）.Conclusion: These findings suggested that CCM could promote the function of immunity in C57BL/6 tumor bearing mice.

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JI Xi-zhong

NING Qing

TAN Wei

ZHANG Run-tong

SONG Jie

CHEN Lanpin

TAN Feng

WEI Xiaoman

Related Institution

The Affiliated Hospital of Nanjing University of Chinese Medicine

Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine for Tumor Prevention and Treatment

The First School of Clinical Medicine of Nanjing University of Chinese Medicine

School of Clinical Medicine of Nanjing University of Chinese Medicine

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

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