TANG Han-qing. Influences of Fuzi Lizhong decoction on Blood Sugar,Triglyceride and Total Cholesterol in Rats with Spleen Yang Deficiency Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 230-233.
TANG Han-qing. Influences of Fuzi Lizhong decoction on Blood Sugar,Triglyceride and Total Cholesterol in Rats with Spleen Yang Deficiency Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 230-233. DOI: 10.13422/j.cnki.syfjx.2012.15.069.
Influences of Fuzi Lizhong decoction on Blood Sugar,Triglyceride and Total Cholesterol in Rats with Spleen Yang Deficiency Syndrome
Objective:To explore influences of Fuzi Lizhong decoction on blood sugar
triglyceride and total cholesterol in rats with spleen yang deficiency syndrome.Method: The rats were randomly divided into four groups
16 cases each group ①control group: fed with ordinary food and water.②yang deficiency syndrome group: the same as the control group’ except removing brown adipose tissue.③spleen yang deficiency syndrome group: the same as the yang deficiency syndrome group except that fed with high fatty diet(including 83% ordinary diet
15% triglycerides
2% cholesterol) and placed in circumstance of 19 ℃.④Chinese herbal decoction group: the same as the spleen yang deficiency syndrome group’ except ig 4 g·kg-1 each day with Fuzi Lizhong decoction.On the first day after 4 weeks blood from left common carotid artery was collected in all the rats in the four groups and then to test the content of blood sugar
triglyceride
total cholesterol.Result: ① Content of blood sugar: compared with control group(5.41±0.080)mmol·L-1
content of blood sugar was lower than that in yang deficiency syndrome group(1.40±0.071) mmol·L-1(P<0.01);compared with yang deficiency syndrome group
content of blood sugar in spleen yang deficiency syndrome group(5.81±0.081) mmol·L-1 was higher(P<0.01);compared with yang deficiency syndrome group
content of blood sugar in Chinese herbal decoction group(5.01±0.080) was higher(P<0.01).② Content of triglyceride: compared with control group(0.487±0.076)mmol·L-1
content of triglyceride was lower than that in yang deficiency syndrome group(0.284±0.11) mmol·L-1(P<0.01);compared with yang deficiency syndrome group
content of triglyceride in spleen yang deficiency syndrome group(0.62±0.184) mmol·L-1 was higher(P<0.01);compared with yang deficiency syndrome group
content of triglyceride in Chinese herbal decoction group(0.462±0.111) mmol·L-1 was higher(P<0.01).③ Content of total cholesterol compared with control group(0.081±0.020)mmol·L-1
content of total cholesterol in both spleen yang deficiency syndrome group(0.183±0.025) mmol·L-1 and Chinese herbal decoction group(0.211±0.026) mmol·L-1 was higher(P<0.01).Conclusion: Fuzi Lizhong decoction can decrease the content of triglyceride and increase use of glucose and its metabolism and then causes its levels lower.Fuzi Lizhong decoction embodies its effect of refreshing spleen in traditional Chinese medicine by recovering the normal metabolism of blood sugar and lipids.